Results 31 to 40 of about 125,059 (252)

Digitalisierung der vollständigen deutschsprachigen Zeitungen des 17. Jahrhunderts in der SuUB Bremen: Ein Werkstattbericht

o-bib. Das offene Bibliotheksjournal, 2014
Seit Mai 2013 fördert die Deutsche Forschungsgemeinschaft (DFG) Pilotprojekte zur Digitalisierung historischer Zeitungen in vier Bibliotheken Deutschlands, darunter in der Staats- und Universitätsbibliothek Bremen.
Maria Hermes, Maria Elisabeth Müller
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Spectroscopic and theoretical evaluation of feruloyl derivatives: Insights into their electronic properties

Results in Chemistry
The spectroscopic characterization of ferulic acid (FA), ethyl ferulate (EF), 1-feruloyl-glycerol (FG), and 1,3-diferuloyl-glycerol (DFG) was done using absorbance spectrophotometry and fluorescence excitation-emission matrix (EEM) analysis.
Kervin O. Evans, David L. Compton, Michael Appell   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Association between low fasting glucose of the living donor and risk of graft loss in the recipient after liver transplantation

Scientific Reports
Several donor-specific factors influence the functional recovery and long-term outcomes of liver grafts. This study investigated the association between donor fasting glucose (DFG) and recipient outcomes after living donor liver transplantation (LDLT) in
Hwa-Hee Koh, Minyoung Lee, Minyu Kang, Seung Hyuk Yim, Mun Chae Choi, Eun-Ki Min, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim, Jae Seung Lee, Deok-Gie Kim   +10 more
doaj   +1 more source

Bericht über die Pilotphase Handschriftendigitalisierung der deutschen Handschriftenzentren

o-bib. Das offene Bibliotheksjournal, 2014
Im Juni 2013 genehmigte die DFG die Durchführung einer zweijährigen Pilotphase zur Digitalisierung mittelalterlicher Handschriften an den deutschen Handschriftenzentren.
Carolin Schreiber
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source