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DHEA treatment: myth or reality?

open access: yesTrends in Endocrinology and Metabolism, 2002
Dehydroepiandrosterone (DHEA) and its sulfate ester are major secretory products of the human adrenal. Serum DHEA concentrations decline with advancing age and DHEA supplementation in elderly people has been advertized as anti-aging medication.
Wiebke Arlt
exaly   +1 more source
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DHEA and DHEA‐S: A Review

The Journal of Clinical Pharmacology, 1999
Dehydroepiandrosterone (DHEA) and its sulfated metabolite DHEA‐S are endogenous hormones secreted by the adrenal cortex in response to adrenocorticotrophin (ACTH). Much has been published regarding potential effects on various systems. Despite the identification of DHEA and DHEA‐S more than 50 years ago, there is still considerable controversy as to ...
P D, Kroboth   +4 more
openaire   +2 more sources

A tale of two steroids: The importance of the androgens DHEA and DHEAS for early neurodevelopment.

Journal of Steroid Biochemistry and Molecular Biology, 2019
DHEA and DHEAS are neuroactive neurosteroids that interact with several major receptor systems in the brain, including sigma (σ), glutamate, and GABA-A receptors.
R. Greaves   +6 more
semanticscholar   +1 more source

Selective Microbial Conversion of DHEA into 7α-OH-DHEA

2023
7α-Hydroxy dehydroepiandrosterone (7α-OH-prasterone, 7α-OH-DHEA) is a key steroid intermediate in the synthesis of valuable pharmaceuticals widely used in the treatment of autoimmune illness, rheumatoid arthritis, colitis, and other severe diseases. The steroid can be produced using a filamentous fungus, which is capable of regio- and stereospecific ...
Vyacheslav V, Kollerov   +2 more
openaire   +2 more sources

DHEA and cognitive function in the elderly

Journal of Steroid Biochemistry and Molecular Biology, 2015
Marcello Maggio   +2 more
exaly   +2 more sources

Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer’s Disease

Current Alzheimer Research, 2020
Background:Neurosteroids Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulphate (DHEAS) are involved in many important brain functions, including neuronal plasticity and survival, cognition and behavior, demonstrating preventive and therapeutic potential in different neuropsychiatric and neurodegenerative disorders, including Alzheimer’s ...
Nedić Erjavec, Gordana   +5 more
openaire   +2 more sources

Biotransformation of DHEA into 7α,15α-diOH-DHEA

2017
3β,7α,15α-Trihydroxy-5-androsten-17-one (7α,15α-diOH-DHEA) is a key intermediate of the novel oral contraceptive "Yasmin" (widely used in birth control pills and postmenopausal hormone replacement therapy pills; the active ingredient is drospirenone).
Hui, Li, Jin, Sun, Zhenghong, Xu
openaire   +2 more sources

Dehydroepiandrosterone (DHEA): Hypes and Hopes

Drugs, 2014
Paweł Sowa   +2 more
exaly   +2 more sources

Neurobiology of DHEA and effects on sexuality, mood and cognition

Journal of Steroid Biochemistry and Molecular Biology, 2015
N Pluchino   +2 more
exaly   +2 more sources

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