Molecular modeling, synthesis and biological evaluation of caffeic acid based Dihydrofolate reductase inhibitors [PDF]
BMC ChemistryDihydrofolate reductase (DHFR) is an enzyme that plays a crucial role in folate metabolism, which is essential for cell growth and division. DHFR has been identified as a molecular target for numerous diseases due to its significance in various ...
Renu Sehrawat +4 more
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SycE allows secretion of YopE–DHFR hybrids by the Yersinia enterocolitica type III Ysc system [PDF]
Molecular Microbiology, 2002 Mario F. Feldman +3 more
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DHFR 19‐bp insertion/deletion polymorphism and MTHFR C677T in adult acute lymphoblastic leukaemia: Is the risk reduction due to intracellular folate unbalancing? [PDF]
American journal of hematology/oncology, 2009 Donato Gemmati +11 more
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Transcriptomic Insights Into Serum-Free Medium Adaptation and Temperature Reduction in Chinese Hamster Ovary Cell Cultures. [PDF]
Biotechnol JGraphical Abstract and Lay Summary Transcriptomic analysis of CHO cells exposed to different industrially relevant conditions identified cholesterol and p53‐related genes with differential expression and several new housekeeping genes. ABSTRACT Chinese hamster ovary (CHO) cells are widely used in recombinant biopharmaceutical production; yet, yields ...
Synoground BF +6 more
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PCFT-Independent Cellular Uptake of Cyclic Cell-Penetrating Peptide-Conjugated Folic Acid. [PDF]
ChembiochemCell‐penetrating peptide (CPP)‐conjugated folic acid mediates efficient internalization of folic acid that is independent of the presence of proton‐coupled folate transporter (PCFT) on the intestinal cells. CPP‐conjugated folic acid demonstrates superior cellular uptake at all studied pH and in the presence of PCFT inhibitors and shows enhanced ...
Mishra VK +3 more
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Pathogens, 2023 Intermittent preventive treatment in pregnancy with sulfadoxine and pyrimethamine (IPTp-SP) is a key component in the malaria control strategy implemented in Africa. The aim of this study was to determine IPTp-SP adherence and coverage, and the impact on
Carole Else Eboumbou Moukoko +12 more
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Antibiotics, 2021 Herein, a series of novel hybrid sulfaguanidine moieties, bearing 2-cyanoacrylamide 2a–d, pyridine-2-one 3–10, and 2-imino-2H-chromene-3-carboxamide 11, 12 derivatives, were synthesized, and their structure confirmed by spectral data and elemental ...
A. Ragab +6 more
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Bioinformatics and Biology Insights, 2023 Dihydrofolate reductase (DHFR) is a crucial enzyme that catalyzes the conversion of folic acid. Its reserved properties and significance in both human (h-DHFR) and mycobacterium (mt-DHFR) make it a challenging target for developing drugs against cancer ...
Ghyzlane EL Haddoumi +8 more
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Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase. [PDF]
PLoS ONE, 2011 Histidine Hydrogen-Deuterium Exchange Mass Spectrometry (His-HDX-MS) determines the HDX rates at the imidazole C(2)-hydrogen of histidine residues. This method provides not only the HDX rates but also the pK(a) values of histidine imidazole rings.
Masaru Miyagi +6 more
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