Results 231 to 240 of about 40,426 (262)

Transcriptomic Insights Into Serum-Free Medium Adaptation and Temperature Reduction in Chinese Hamster Ovary Cell Cultures. [PDF]

Biotechnol J
Synoground BF, Gowtham Y, Lindquist T, Pressley J, Scott DC, Saski CS, Harcum SW.   +6 more
europepmc   +1 more source

In Silico Investigation of Phytochemicals From Clinically Tested Herbal Extracts as Potential Dihydrofolate Reductase Inhibitors for Buruli Ulcer. [PDF]

Biomed Res Int
Mohamed AAK, Woasiedem T, Appiah-Ofori PC, Adam EMA, Obiri SA, Borquaye LS, Adokoh CK, Elamin G, Asiamah I.   +8 more
europepmc   +1 more source

Exploring the therapeutic potential of baicalin against MCF-7 breast cancer cells: biochemical, <i>in vitro</i>, and computational perspectives. [PDF]

Front Pharmacol
Ali A, Upadhyay TK, Al-Keridis LA, Alshahrani MY, Alshamamri N, Saeed M.   +5 more
europepmc   +1 more source

Trigger factor accelerates nascent chain compaction and folding. [PDF]

Proc Natl Acad Sci U S A
Till K, Seinen AB, Wruck F, Sunderlikova V, Galmozzi CV, Katranidis A, Bukau B, Kramer G, Tans SJ.   +8 more
europepmc   +1 more source

Changes of folate constituents and contents in pakchoi as affected by nitrate to ammonium ratio in nutrient solution under hydroponic conditions. [PDF]

J Zhejiang Univ Sci B
Zhu Y, Cheng W, Ni Y, Ni W.
europepmc   +1 more source

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Insights into antifolate resistance from malarial DHFR-TS structures

Nature Structural and Molecular Biology, 2003
Penchit Chitnumsub, Sumalee Kamchonwongpaisan, Jarunee Vanichtanankul   +2 more
exaly   +2 more sources

DihydrofolateReductase (DHFR) Inhibitors: A Comprehensive Review.

Current Medicinal Chemistry, 2023
BACKGROUND Dihydrofolate reductase (DHFR) is an indispensable enzyme required for the survival of most prokaryotic and eukaryotic cells as it is involved in the biosynthesis of essential cellular components.
Renu Sehrawat, P. Rathee, Sarita Khatkar, E. Akkol, M. Khayatkashani, S. Nabavi, A. Khatkar   +6 more
semanticscholar   +1 more source

3D-QSAR, molecular docking, DFT and ADMET studies on quinazoline derivatives to explore novel DHFR inhibitors

Journal of Biomolecular Structure and Dynamics, 2021
Resistance to folate antagonists is caused by mutations in the dihydrofolate reductase (DHFR) genes. These mutations affect the amino acids at positions 51, 59, 108 and 164 of DHFR, which appear to play a major role in malaria treatment failure ...
Hanine Hadni, M. Bakhouch, M. Elhallaoui
semanticscholar   +1 more source

Recent Design and Structure-Activity Relationship Studies on Modifications of DHFR Inhibitors as Anticancer Agents.

Current Medicinal Chemistry, 2019
BACKGROUND Dihydrofolate reductase (DHFR) has been known for decades as a molecular target for antibacterial, antifungal and anti-malarial treatments.
Agnieszka Wróbel, D. Drozdowska
semanticscholar   +1 more source