Results 21 to 30 of about 40,426 (262)

Common Origin and Fixation of Plasmodium falciparum dhfr and dhps Mutations Associated with Sulfadoxine-Pyrimethamine Resistance in a Low-Transmission Area in South America

Antimicrobial Agents and Chemotherapy, 2007
Leopoldo Villegas, Ananias A Escalante
exaly   +2 more sources

High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations

Malaria Journal, 2017
Background Emergence and spread of drug resistance to every anti-malarial used to date, creates an urgent need for development of sensitive, specific and field-deployable molecular tools for detection and surveillance of validated drug resistance markers.
Yaye Dié Ndiaye, Cyrille K. Diédhiou, Amy K. Bei, Baba Dieye, Aminata Mbaye, Nasserdine Papa Mze, Rachel F. Daniels, Ibrahima M. Ndiaye, Awa B. Déme, Amy Gaye, Mouhamad Sy, Tolla Ndiaye, Aida S. Badiane, Mouhamadou Ndiaye, Zul Premji, Dyann F. Wirth, Souleymane Mboup, Donald Krogstad, Sarah K. Volkman, Ambroise D. Ahouidi, Daouda Ndiaye   +20 more
doaj   +1 more source

Berberine: A Potential Inhibitor of Dihydrofolate Reductase- Thymidylate Synthase (DHFR-TS) for Malaria

Biosfer: Jurnal Tadris Biologi, 2022
The goal of this study was to genetically link natural materials derived from Tinospora crispa L with Berberine to dihydrofolate reductase-thymidylate synthase (DHFR-TS).
Yohanes Bare, Dewi Ratih Tirto Sari, Angeliana Desimaris Nita, Maximus M Taek   +3 more
doaj   +1 more source

Sampling of conformational ensemble for virtual screening using molecular dynamics simulations and normal mode analysis [PDF]

, 2015
Aim: Molecular dynamics simulations and normal mode analysis are well-established approaches to generate receptor conformational ensembles (RCEs) for ligand docking and virtual screening.
David Perahia, Divij Goyal, Gautier Moroy, Karen Druart, Maria A Miteva, Miteva MA, Olivier Sperandio, Saurabh Khemka, Shakti Rielland, Trott O, Xu X   +10 more
core   +4 more sources

Mitochondrial Protein Import [PDF]

, 1987
The role of nucleoside triphosphates (NTPs) in mitochondrial protein import was investigated with the precursors of N. crassa ADP/ATP carrier, F1-ATPase subunit β, F0-ATPase subunit 9, and fusion proteins between subunit 9 and mouse dihydrofolate ...
Arends, Argan, Argan, Bogner, Bogner, Bradford, Böhni, Böhni, Chamberlain, Chen, Chen, Conboy, Eilers, Emr, Firgaira, Flügge, Frank, Gasser, Geller, Grossman, Gubler, Hanahan, Hansen, Harmey, Hartl, Hay, Hennig, Hennig, Horwich, Hurt, Hurt, Jaenicke, Keng, Kolanski, Maniatis, McAda, Miura, Miura, Mueckler, Nicholls, Nunberg, Ohta, Pelham, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Randall, Riezman, Roise, Rothblatt, Rothman, Schlenstedt, Schleyer, Schleyer, Schleyer, Schmidt, Schmidt, Schwaiger, Sebald, Stueber, van Loon, van Loon, Viebrock, Waters, Wiech, Wikstrom, Zimmermann, Zimmermann, Zwizinski, Zwizinski, Zwizinski   +72 more
core   +4 more sources

Antimalarial Drug Pyrimethamine Plays a Dual Role in Antitumor Proliferation and Metastasis through Targeting DHFR and TP

Molecular Cancer Therapeutics, 2019
Pyrimethamine (Pyr), an antimalarial drug that targeting plasmodium dihydrofolate reductase (pDHFR), has been proved to have antitumor activity. However, its direct target on cancer cells remains unclear.
Hui-juan Liu, Yuan Qin, Deng-hui Zhai, Qiang Zhang, Ju Gu, Yuanhao Tang, Jiahuan Yang, Kun Li, Lan Yang, Shuang Chen, Wei-long Zhong, Jing Meng, Yanrong Liu, Tao Sun, Cheng Yang   +14 more
semanticscholar   +1 more source

Overproduction of PDR3 Suppresses Mitochondrial Import Defects Associated with a TOM70 Null Mutation by Increasing the Expression of TOM72 in Saccharomyces cerevisiae [PDF]

, 2001
Most mitochondrial proteins are synthesized with cleavable amino-terminal targeting signals that interact with the mitochondrial import machinery to facilitate their import from the cytosol.
Bedwell, David M., Hájek, Petr, Koh, Julie Y.   +2 more
core   +1 more source

Antifolate Resistance inPlasmodium falciparum:Multiple Origins and Identification of NoveldhfrAlleles

Journal of Infectious Diseases, 2006
Ananias A Escalante
exaly   +2 more sources

Design, synthesis, and biological evaluation of novel N4-substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

BMC Chemistry, 2019
BackgroundSulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit antimicrobial and anticancer activities.
E. Hussein, M. Al‐Rooqi, Shimaa M. Abd El-Galil, Saleh A. Ahmed   +3 more
semanticscholar   +1 more source

Protein folding causes an arrest of preprotein translocation into mitochondria in vivo [PDF]

, 1991
With vital yeast cells, a hybrid protein consisting of the amino- terminal third of the precursor to cytochrome b2 and of the entire dihydrofolate reductase was arrested on the import pathway into mitochondria.
Becker, Karin, Guiard, Bernard, Horwich, Arthur, Neupert, Walter, Pfanner, Nikolaus, Schleyer, Manfred, Tropschug, Maximilian, Wienhues, Ulla   +7 more
core   +3 more sources