Results 21 to 30 of about 39,011 (239)

Design, Synthesis, and Antimicrobial Evaluation of a New Series of N-Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes

ACS Omega, 2020
Sulfonamides and trimethoprim (TMP) drugs are normally used to inhibit the action of dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) enzymes, respectively. In this work, a new series of N-sulfonamide 2-pyridone derivatives that combine
Rasha A. Azzam, Rasha E. Elsayed, G. Elgemeie   +2 more
semanticscholar   +1 more source

Functional expression of parasite drug targets and their human orthologs in yeast. [PDF]

PLoS Neglected Tropical Diseases, 2011
The exacting nutritional requirements and complicated life cycles of parasites mean that they are not always amenable to high-throughput drug screening using automated procedures. Therefore, we have engineered the yeast Saccharomyces cerevisiae to act as
Elizabeth Bilsland, Pınar Pir, Alex Gutteridge, Alexander Johns, Ross D King, Stephen G Oliver   +5 more
doaj   +1 more source

Identification of DHPS and DHFR of pythium insidiosum from the first Chinese skin and subcutaneous pythiosis

Informatics in Medicine Unlocked, 2023
Based on our previous studies, it is speculated that DHPS and DHFR are potential targets for the treatment of pythiosis. The Physicochemical properties, hydrophilicity/hydrophobicity, subcellular localization, signal peptide, secondary structure ...
Haiyan Zhang
doaj   +1 more source

Common Origin and Fixation of Plasmodium falciparum dhfr and dhps Mutations Associated with Sulfadoxine-Pyrimethamine Resistance in a Low-Transmission Area in South America

Antimicrobial Agents and Chemotherapy, 2007
Andrea M. McCollum, Kristen L. Mueller, Leopoldo Villegas, Venkatachalam Udhayakumar, Ananías A. Escalante   +4 more
openalex   +2 more sources

Establishment of a Dihydrofolate Reductase Gene Knock-In Zebrafish Strain to Aid Preliminary Analysis of Congenital Heart Disease Mechanisms

Frontiers in Cardiovascular Medicine, 2021
Background: The dihydrofolate reductase (DHFR) gene is imperative in development, therefore it is essential to explore its effects on heart development. Thus, here a dhfr zebrafish knock-in (KI) strain was constructed.Methods: CRISPR/Cas9 technology was ...
Ke Gong, Ting Xie, Yifeng Yang, Yong Luo, Yun Deng, Yun Deng, Kun Chen, Kun Chen, Zhiping Tan, Zhiping Tan, Hui Guo, Li Xie   +11 more
doaj   +1 more source

High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations

Malaria Journal, 2017
Background Emergence and spread of drug resistance to every anti-malarial used to date, creates an urgent need for development of sensitive, specific and field-deployable molecular tools for detection and surveillance of validated drug resistance markers.
Yaye Dié Ndiaye, Cyrille K. Diédhiou, Amy K. Bei, Baba Dieye, Aminata Mbaye, Nasserdine Papa Mze, Rachel F. Daniels, Ibrahima M. Ndiaye, Awa B. Déme, Amy Gaye, Mouhamad Sy, Tolla Ndiaye, Aida S. Badiane, Mouhamadou Ndiaye, Zul Premji, Dyann F. Wirth, Souleymane Mboup, Donald Krogstad, Sarah K. Volkman, Ambroise D. Ahouidi, Daouda Ndiaye   +20 more
doaj   +1 more source

A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins [PDF]

, 2002
Incorporation of non-natural amino acids into proteins in vivo expands the scope of protein synthesis and design. p-Acetylphenylalanine was incorporated into recombinant dihydrofolate reductase (DHFR) in Escherichia coli via a computationally designed ...
Carrico, Isaac S., Datta, Deepshikha, Mayo, Stephen L., Tirrell, David A., Wang, Pin   +4 more
core   +2 more sources

Berberine: A Potential Inhibitor of Dihydrofolate Reductase- Thymidylate Synthase (DHFR-TS) for Malaria

Biosfer: Jurnal Tadris Biologi, 2022
The goal of this study was to genetically link natural materials derived from Tinospora crispa L with Berberine to dihydrofolate reductase-thymidylate synthase (DHFR-TS).
Yohanes Bare, Dewi Ratih Tirto Sari, Angeliana Desimaris Nita, Maximus M Taek   +3 more
doaj   +1 more source

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

Molecules, 2019
Dihydrofolate reductase inhibitors are an important class of drugs, as evidenced by their use as antibacterial, antimalarial, antifungal, and anticancer agents.
M. V. Raimondi, O. Randazzo, Mery La Franca, G. Barone, E. Vignoni, D. Rossi, S. Collina   +6 more
semanticscholar   +1 more source

Molecular determinants of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum in Nigeria and the regional emergence of dhps 431V

International Journal for Parasitology: Drugs and Drug Resistance, 2016
There are few published reports of mutations in dihydropteroate synthetase (dhps) and dihydrofolate reductase (dhfr) genes in P. falciparum populations in Nigeria, but one previous study has recorded a novel dhps mutation at codon 431 among infections ...
Mary C. Oguike, Catherine O. Falade, Elvis Shu, Izehiuwa G. Enato, Ismaila Watila, Ebenezer S. Baba, Jane Bruce, Jayne Webster, Prudence Hamade, Sylvia Meek, Daniel Chandramohan, Colin J. Sutherland, David Warhurst, Cally Roper   +13 more
doaj   +1 more source