Results 31 to 40 of about 40,426 (262)

A Peroxisomal Lon Protease and Peroxisome Degradation by Autophagy Play Key Roles in Vitality of Hansenula polymorpha Cells [PDF]

, 2007
In eukaryote cells various mechanisms exist that are responsible for the removal of non-functional proteins. Here we show that in the yeast Hansenula polymorpha (H.
Bener Aksam, Eda, Jourdan, Stefanie, Kiel, Jan A.K.W., Klei, Ida J. van der, Koek, Anne, Veenhuis, Marten   +5 more
core   +2 more sources

Homology modelling, molecular docking, and molecular dynamics simulations reveal the inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase enzyme by Withaferin-A

BMC Research Notes, 2018
Objective Present in silico study was carried out to explore the mode of inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase (Ld DHFR-TS) enzyme by Withaferin-A, a withanolide isolated from Withania somnifera. Withaferin-A (WA)
Bharadwaja Vadloori, A. K. Sharath, N. Prakash Prabhu, Radheshyam Maurya   +3 more
doaj   +1 more source

Protective efficacy of intermittent preventive treatment of malaria in infants (IPTi) using sulfadoxine-pyrimethamine and parasite resistance. [PDF]

PLoS ONE, 2010
BACKGROUND: Intermittent Preventive Treatment of malaria in infants using sulfadoxine-pyrimethamine (SP-IPTi) is recommended by WHO for implementation in settings where resistance to SP is not high. Here we examine the relationship between the protective
Jamie T Griffin, Matthew Cairns, Azra C Ghani, Cally Roper, David Schellenberg, Ilona Carneiro, Robert D Newman, Martin P Grobusch, Brian Greenwood, Daniel Chandramohan, Roly D Gosling   +10 more
doaj   +1 more source

DHFR and MDR1 upregulation is associated with chemoresistance in osteosarcoma stem-like cells

Oncology Letters, 2017
Tumor-initiating cells (TICs) are defined as a specialized subset of cells with tumor-initiating capacity that can initiate tumor growth, tumor relapse and metastasis.
Yu-Hsien Lee, Hui-wen Yang, Li-Chiu Yang, Ming-Yi Lu, L. Tsai, Shun-Fa Yang, Yu-Feng Huang, M. Chou, Cheng-Chia Yu, Fang-Wei Hu   +9 more
semanticscholar   +1 more source

Plasmodium falciparum Genetic Diversity and Resistance Genotype Profile in Infected Placental Samples Collected After Delivery in Ouagadougou

Infection and Drug Resistance, 2023
Haffsatou Sawadogo,1,2 Issiaka Soulama,3,4 Adama Zida,2,5 Cheikna Zongo,1 Patindoilba Marcel Sawadogo,2,5 Kiswendsida Thierry Guiguemde,5,6 Seni Nikiema,7 Salimata Emilie Badoum,1,8 Salam Sawadogo,7 Aïcha Tou,4 Salif Sombié,4 Chanolle Tchekounou,1,9 ...
Sawadogo H, Soulama I, Zida A, Zongo C, Sawadogo PM, Guiguemde KT, Nikiema S, Badoum SE, Sawadogo S, Tou A, Sombié S, Tchekounou C, Sermé SS, Ouedraogo-Traoré R, Guiguemdé TR, Savadogo A   +15 more
doaj  

Multiple prebiotic metals mediate translation. [PDF]

, 2018
Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life's oldest macromolecular machine, the translation system. We tested whether ancient Earth conditions (low O2, high Fe2+, and high Mn2+) can revert the ribosome to a ...
Bowman, Jessica C, Bray, Marcus S, Glass, Jennifer B, Haynes, Jay William, Hud, Nicholas V, Lenz, Timothy K, Petrov, Anton S, Reddi, Amit R, Williams, Loren Dean   +8 more
core   +1 more source

Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation

Cancer Cell International, 2016
BackgroundMethotrexate is an important chemotherapeutic drug widely known as an inhibitor of dihydrofolate reductase (DHFR) which inhibits the reduction of folic acid. DHFR-mediated effects are apparently responsible for its primary antineoplastic action.
M. Šrámek, J. Neradil, J. Štěrba, R. Veselska   +3 more
semanticscholar   +1 more source

Conformational Dynamics of the Plug Domain of the SecYEG Protein-conducting Channel [PDF]

, 2011
The central pore of the SecYEG preprotein-conducting channel is closed at the periplasmic face of the membrane by a plug domain. To study its conformational dynamics, the plug was labeled site-specifically with an environment-sensitive fluorophore.
Arkowitz, Baneyx, Becker, Bol, Bonardi, Bondar, Cabelli, De Keyzer, Driessen, du Plessis, Duong, Egea, Evans, Fekkes, Frauenfeld, Greenough, Gumbart, Hanahan, Harris, Joly, Junne, Klose, Kusters, Lakowicz, Li, Lin, Lycklama, Maillard, Manting, Ménétret, Nakatogawa, Osborne, Plath, Prinz, Ramachandran, Rutkowska, Schaffitzel, Smith, Tam, Tsukazaki, Van den Berg, van der Does, van der Sluis, Zhang, Zimmer   +44 more
core   +2 more sources

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum.

PLoS Neglected Tropical Diseases, 2021
Our understanding of folate metabolism in Leishmania has greatly benefited from studies of resistance to the inhibitor methotrexate (MTX). Folates are reduced in Leishmania by the bifunctional dihydrofolate reductase thymidylate synthase (DHFR-TS) and by
Arijit Bhattacharya, Philippe Leprohon, Marc Ouellette   +2 more
doaj   +1 more source

Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Leishmania Species

Antibiotics, 2023
The bifunctional enzyme Dihydrofolate reductase-thymidylate synthase (DHFR-TS) plays a crucial role in the survival of the Leishmania parasite, as folates are essential cofactors for purine and pyrimidine nucleotide biosynthesis. However, DHFR inhibitors
Chonny Herrera-Acevedo, Renata Priscila Barros de Menezes, Natália Ferreira de Sousa, Luciana Scotti, Marcus Tullius Scotti, Ericsson Coy-Barrera   +5 more
doaj   +1 more source