Results 21 to 30 of about 430 (81)
Frontiers in Immunology, 2021 Porphyromonas gingivalis, a bacterium associated with periodontal disease, is a suspected cause of Alzheimer’s disease. This bacterium is reliant on gingipain proteases, which cleave host proteins after arginine and lysine residues.
Sejal Patel +10 more
doaj +1 more source
Engineering chimeric antigen receptor T cells for solid tumour therapy
Clinical and Translational Medicine, Volume 12, Issue 12, December 2022., 2022 The tumour microenvironment (TME) is a complex and evolving entity composed of different cell types, vasculature, soluble factors and extracellular matrix, with each component playing a critical role in affecting chimeric antigen receptor T (CAR‐T) cell immunotherapy.
Longwei Liu +8 more
wiley +1 more source
Disorders of Sex Development in a Large Ukrainian Cohort: Clinical Diversity and Genetic Findings
Frontiers in Endocrinology, 2022 BackgroundThe clinical profile and genetics of individuals with Disorders/Differences of Sex Development (DSD) has not been reported in Ukraine.Materials and MethodsWe established the Ukrainian DSD Register and identified 682 DSD patients.
Evgenia Globa +5 more
doaj +1 more source
Molecular Genetics &Genomic Medicine, Volume 10, Issue 12, December 2022., 2022 Differences of sex development (DSD) is a term used for conditions in which the chromosomal, gonadal, or phenotypical sex is atypical. 46,XY DSD patients frequently present with undervirilized external genitalia. Our results showed higher expression of miR‐210 in plasma samples from 46,XY DSD patients with atypical genitalia, characterized by the ...
Felipe Martins Elias +9 more
wiley +1 more source
Human Mutation, Volume 43, Issue 3, Page 420-433, March 2022., 2022 Endocytic uptake of testosterone (T) bound to SHBG or another protein (??) via LRP2 or LMBR1L. Abstract Transporter‐dependent steroid hormone uptake into target cells was demonstrated in genetically engineered mice and fruit flies. We hypothesized that mutations in such transporters may cause differences in sex development (DSD) in humans.
Hannah L. Marko +9 more
wiley +1 more source
Journal of Immunology Research, 2020 Background. RNA helicases have various essential functions in basically all aspects of RNA metabolism, not only unwinding RNA but also disturbing the interaction of RNA with proteins.
Yanni Xu +6 more
doaj +1 more source
A Risk Model Based on Sorafenib‐Response Target Genes Predicts the Prognosis of Patients with HCC
Journal of Oncology, Volume 2022, Issue 1, 2022., 2022 Sorafenib is used to treat digestive system tumors in patients who do not respond to or cannot tolerate surgery. However, the roles and inhibitory mechanisms of sorafenib against hepatocellular carcinoma (HCC) are unclear. Differentially expressed genes in tissues from responders and nonresponders to sorafenib were investigated using the HCC GSE109211 ...
Xiang Liu +9 more
wiley +1 more source
Clinical Endocrinology, Volume 95, Issue 6, Page 818-840, December 2021., 2021 Abstract It is paramount that any child or adolescent with a suspected difference or disorder of sex development (DSD) is assessed by an experienced clinician with adequate knowledge about the range of conditions associated with DSD and is discussed with the regional DSD service. In most cases, the paediatric endocrinologist within this service acts as
S. Faisal Ahmed +13 more
wiley +1 more source
Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
Advanced Science, Volume 8, Issue 22, November 17, 2021., 2021 The progress of anti‐tumor immunity is reviewed. Recent findings of CD4+ T cell, CD8+ T cell, T cell exhaustion and B cell are provided. Several anti‐tumor immunotherapies based on different immune cells in these years and prospects of anti‐tumor immunotherapies are also discussed.
Yifan Xie +9 more
wiley +1 more source
Molecular Ecology, Volume 30, Issue 14, Page 3530-3547, July 2021., 2021 Abstract Organisms well suited for the study of ecotype formation have wide distribution ranges, where they adapt to multiple drastically different habitats repeatedly over space and time. Here we study such ecotypes in a Crustacean model, Asellus aquaticus, a commonly occurring isopod found in freshwater habitats as diverse as streams, caves and lakes.
Vid Bakovic +6 more
wiley +1 more source