Results 21 to 30 of about 512 (102)

DHX37 protein and mRNA expression patterns in breast and ovarian cancer and their prognostic implications. [PDF]

Histochem Cell Biol
DEAH-box RNA helicase 37 (DHX37) is a highly conserved RNA helicase involved in ribosome biogenesis, RNA metabolism and immune regulation. Dysregulation of RNA helicases has been implicated in tumourigenesis; however, the clinical significance of DHX37 ...
Ndeke D, Sam S, Polchai N, Alshammari K, Greener MR, Marak TR, Joyce J, Henman M, Deen S, Green AR, Ellis IO, Rakha EA, Martin SG, Storr SJ.   +13 more
europepmc   +2 more sources

Novel and Known <i>DHX37</i> Variants in 46,XY DSD: Expanding the Genotypic and Phenotypic Spectrum. [PDF]

Genes (Basel)
Objective: To investigate the clinical characteristics, inheritance patterns, and genotype–phenotype correlations of DHX37 variants in 46,XY disorders of sex development (DSD).
Xu X, Wu X, Chen S, Miao H, Fang K, Wu D, Zhang Y, Yang X.   +7 more
europepmc   +2 more sources

Supplementary Table from RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1

, 2022
Supplementary Table from RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin ...
Huifang Chen (1513990), Zhen Wang (72451), Zhiao Chen (14941047), Zhen Liu (74646), Youqiong Ye (14954662), Yizhe Liu (3903880), Xianghuo He (14941050), Leng Han (9018434), Yanfang Liu (306148), Mengting Shen (14954665), Shenglin Huang (123385)   +10 more
core   +5 more sources

Etiology, histology, and long-term outcome of bilateral testicular regression: a large Belgian series. [PDF]

Hum Reprod Open, 2023
STUDY QUESTION: What is the long-term outcome of individuals born with bilateral testicular regression (BTR) in relation to its underlying etiology?
Tack LJW, Brachet C, Beauloye V, Heinrichs C, Boros E, De Waele K, van der Straaten S, Van Aken S, Craen M, Lemay A, Rochtus A, Casteels K, Beckers D, Mouraux T, Logghe K, Van Loocke M, Massa G, Van de Vijver K, Syryn H, Van De Velde J, De Baere E, Verdin H, Cools M.   +22 more
europepmc   +2 more sources

RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1 [PDF]

Cancer Research, 2022
Youqiong Ye, Xianghuo He, Huifang Chen   +2 more
exaly   +2 more sources

Machine Learning Screens Potential Drugs Targeting a Prognostic Gene Signature Associated With Proliferation in Hepatocellular Carcinoma

Frontiers in Genetics, 2022
Background: This study aimed to screen potential drugs targeting a new prognostic gene signature associated with proliferation in hepatocellular carcinoma (HCC).Methods: CRISPR Library and TCGA datasets were used to explore differentially expressed genes
Jun Liu, Jun Liu, Jianjun Lu, Wenli Li, Wenjie Mao, Yamin Lu   +5 more
doaj   +1 more source

Regulation and function of poised mRNAs in lymphocytes

BioEssays, Volume 45, Issue 5, May 2023., 2023
Poised transcripts are messenger RNAs that are not being translated but can be translated in response to stimuli. In lymphocytes poised transcripts encode cytokines and other proteins involved in cell fate. Candidate mechanisms for reversible transcript poising involving RNA binding proteins and the chemical, structural or spatial modification of mRNA ...
Martin Turner
wiley   +1 more source

FGF9 variant in 46,XY DSD patient suggests a role for dimerization in sex determination

Clinical Genetics, Volume 103, Issue 3, Page 277-287, March 2023., 2023
Immunofluorescence analysis in a FGF9‐D195N mouse model: XY Fgf9D195N/− mice show partial gonadal sex reversal, expressing the meiotic germ cell marker γH2AX (b) and the ovarian somatic cell marker FOXL2 (d). XY Fgf9+/− mice were used as controls (a, c). AMH is a marker of testicular Sertoli cells. Scale bars 100 μm.
Brittany Croft, Anthony D. Bird, Makoto Ono, Stefanie Eggers, Stefan Bagheri‐Fam, Janelle M. Ryan, Alejandra P. Reyes, Jocelyn van den Bergen, Anne Baxendale, Elizabeth M. Thompson, Andrew J. Kueh, Peter Stanton, Tim Thomas, Andrew H. Sinclair, Vincent R. Harley   +14 more
wiley   +1 more source

DHX37 and 46, XY DSD : A new Ribosomopathy?

, 2022
International audienceRecently, a series of recurrent missense variants in the RNA-helicase DHX37 have been reported associated with either 46,XY gonadal dysgenesis, 46,XY testicular regression syndrome (TRS), or anorchia.
Pailhoux, Eric, Bashamboo, Anu, Mcelreavey, Kenneth   +2 more
core   +1 more source

Characterization of Human Genes Modulated by Porphyromonas gingivalis Highlights the Ribosome, Hypothalamus, and Cholinergic Neurons

Frontiers in Immunology, 2021
Porphyromonas gingivalis, a bacterium associated with periodontal disease, is a suspected cause of Alzheimer’s disease. This bacterium is reliant on gingipain proteases, which cleave host proteins after arginine and lysine residues.
Sejal Patel, Derek Howard, Nityananda Chowdhury, Casey Derieux, Bridgette Wellslager, Özlem Yilmaz, Özlem Yilmaz, Leon French, Leon French, Leon French, Leon French   +10 more
doaj   +1 more source