Results 31 to 40 of about 430 (81)

DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4

Thoracic Cancer, Volume 12, Issue 12, Page 1873-1880, June 2021., 2021
DEAD/H box RNA helicase 10 (DDX10) is significantly upregulated in lung cancer. DDX10 knockdown significantly inhibited the proliferation of lung cancer cells in vitro and in vivo. IMP4 overexpression could reverse the effect of DDX10 knockdown on the proliferation and apoptosis of lung cancer cells.
Chunquan Liu, Jizheng Tang, Xinchun Duan, Yanlin Du, Xiaoran Wang, Yong Cui   +5 more
wiley   +1 more source

Integrative Expression and Prognosis Analysis of DHX37 in Human Cancers by Data Mining

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
DHEA‐Box Helicase 37 (DHX37) is a putative RNA helicase. It is involved in various RNA secondary structure alteration processes, including translation, nuclear splicing, and ribosome assembly. It is reported to be associated with the neurodevelopmental disorder with brain anomalies, and a recent study suggests that DHX37 is a functional regulator of ...
Kang Huang, Tudi Pang, Changjun Tong, Houqing Chen, Yupeng Nie, Jiayi Wu, Yandong Zhang, Ganghong Chen, Wei Zhou, Dazhi Yang, Bing Niu   +10 more
wiley   +1 more source

Research progress in the role of DHX37 gene in disorders of sex development

Shanghai Jiaotong Daxue xuebao. Yixue ban
Disorders of sex development (DSD) are a group of conditions with strong clinical phenotype heterogeneity, and the incidence of DSD in the population is 1/5 000 to 1/4 500.
LIU Bei, HE Jing
doaj   +1 more source

DHX37 and tumor growth: a novel avenue for melanoma research

Journal of Translational Medicine
Introduction This study explores a novel mechanism by which the RNA helicase DHX37 contributes to melanoma and elucidates the reasons for resistance to tumor immunotherapy, providing new insights for the treatment of melanoma.
Ruoxi Chen, Shiliang Dong, Xuanru Zhu, Xiaodong Chu, Hongwei Liu   +4 more
doaj   +1 more source

Unraveling the Genetic Mysteries of Müllerian Anomalies: Research Approaches and Clinical Significance

Clinical Genetics, Volume 109, Issue 4, Page 615-629, April 2026.
This review primarily summarizes the genetic defects in Müllerian anomalies, the tools used to validate these genetic defects, and the future clinical significance of identifying the precise genetic etiology of Müllerian anomalies. ABSTRACT Müllerian anomalies are a collection of heterogeneous anatomical disorders of the female genital tract that ...
Jingfang Li, Xin Hou, Xiangyu Wang, Juan Li, Li Li, Xiangyi Ma   +5 more
wiley   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, Volume 2, Issue 1, Page 106-129, March 2026.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, Volume 6, Issue 5, October 2025.
The recent advancements in the application of CRISPR/Cas9‐edited tumor‐associated immune cells in cancer therapy are summarized, including T lymphoid cells, natural killer cells, macrophages, and B lymphoid cells et al., exhibiting a potential impact on the pathological status of cancer. This review also addresses the current challenges associated with
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source

Increased burden of rare protein‐truncating variants in constrained, brain‐specific and synaptic genes in extremely impulsively violent males with antisocial personality disorder

Genes, Brain and Behavior, Volume 23, Issue 1, February 2024.
We performed whole exome sequencing (WES) in 290 males with the life‐course‐persistent, extremely impulsively violent form of antisocial personality disorder (APD) and analyzed the spectrum of rare protein‐truncating variants (rPTVs). Comparisons were made with 314 male controls and publicly available genotype data. Participants were significantly more
Dita Mušálková, Anna Přistoupilová, Ivana Jedličková, Hana Hartmannová, Helena Trešlová, Lenka Nosková, Kateřina Hodaňová, Petra Bittmanová, Viktor Stránecký, Václav Jiřička, Michaela Langmajerová, Marc Woodbury‐Smith, Mehdi Zarrei, Brett Trost, Stephen W. Scherer, Anthony J. Bleyer, Jan Vevera, Stanislav Kmoch   +17 more
wiley   +1 more source

Unveiling a cuproptosis-related risk model and the role of FARSB in hepatocellular carcinoma

Heliyon
Background: Cuproptosis, a type of regulated cell death that was recently identified, has been linked to the development of a variety of diseases, among them being cancers.
Junlin Duan, Xuan Zhang, Jingyu Xu, Jun Liu, Hetong Zhao   +4 more
doaj   +1 more source

Etiology, histology, and long-term outcome of bilateral testicular regression: a large Belgian series. [PDF]

Hum Reprod Open, 2023
Tack LJW, Brachet C, Beauloye V, Heinrichs C, Boros E, De Waele K, van der Straaten S, Van Aken S, Craen M, Lemay A, Rochtus A, Casteels K, Beckers D, Mouraux T, Logghe K, Van Loocke M, Massa G, Van de Vijver K, Syryn H, Van De Velde J, De Baere E, Verdin H, Cools M.   +22 more
europepmc   +1 more source