Results 31 to 40 of about 512 (102)

Engineering chimeric antigen receptor T cells for solid tumour therapy

Clinical and Translational Medicine, Volume 12, Issue 12, December 2022., 2022
The tumour microenvironment (TME) is a complex and evolving entity composed of different cell types, vasculature, soluble factors and extracellular matrix, with each component playing a critical role in affecting chimeric antigen receptor T (CAR‐T) cell immunotherapy.
Longwei Liu, Yunjia Qu, Leonardo Cheng, Chi Woo Yoon, Peixiang He, Abdula Monther, Tianze Guo, Sarah Chittle, Yingxiao Wang   +8 more
wiley   +1 more source

Disorders of Sex Development in a Large Ukrainian Cohort: Clinical Diversity and Genetic Findings

Frontiers in Endocrinology, 2022
BackgroundThe clinical profile and genetics of individuals with Disorders/Differences of Sex Development (DSD) has not been reported in Ukraine.Materials and MethodsWe established the Ukrainian DSD Register and identified 682 DSD patients.
Evgenia Globa, Natalia Zelinska, Yulia Shcherbak, Joelle Bignon-Topalovic, Anu Bashamboo, Ken MсElreavey   +5 more
doaj   +1 more source

Elevated plasma miR‐210 expression is associated with atypical genitalia in patients with 46,XY differences in sex development

Molecular Genetics &Genomic Medicine, Volume 10, Issue 12, December 2022., 2022
Differences of sex development (DSD) is a term used for conditions in which the chromosomal, gonadal, or phenotypical sex is atypical. 46,XY DSD patients frequently present with undervirilized external genitalia. Our results showed higher expression of miR‐210 in plasma samples from 46,XY DSD patients with atypical genitalia, characterized by the ...
Felipe Martins Elias, Mirian Yumi Nishi, Maria Helena Palma Sircili, Rafael Loch Bastista, Nathalia Lisboa Gomes, Maria Tereza Martins Ferrari, Elaine Maria Frade Costa, Francisco Tibor Denes, Berenice Bilharinho Mendonca, Sorahia Domenice   +9 more
wiley   +1 more source

Genomic variants reducing expression of two endocytic receptors in 46,XY differences of sex development

Human Mutation, Volume 43, Issue 3, Page 420-433, March 2022., 2022
Endocytic uptake of testosterone (T) bound to SHBG or another protein (??) via LRP2 or LMBR1L. Abstract Transporter‐dependent steroid hormone uptake into target cells was demonstrated in genetically engineered mice and fruit flies. We hypothesized that mutations in such transporters may cause differences in sex development (DSD) in humans.
Hannah L. Marko, Nadine C. Hornig, Regina C. Betz, Paul‐Martin Holterhus, Janine Altmüller, Holger Thiele, Marietta Fabiano, Hans‐Udo Schweikert, Doreen Braun, Ulrich Schweizer   +9 more
wiley   +1 more source

A Risk Model Based on Sorafenib‐Response Target Genes Predicts the Prognosis of Patients with HCC

Journal of Oncology, Volume 2022, Issue 1, 2022., 2022
Sorafenib is used to treat digestive system tumors in patients who do not respond to or cannot tolerate surgery. However, the roles and inhibitory mechanisms of sorafenib against hepatocellular carcinoma (HCC) are unclear. Differentially expressed genes in tissues from responders and nonresponders to sorafenib were investigated using the HCC GSE109211 ...
Xiang Liu, Jian Zeng, Huanyu Li, Feng Li, Bin Jiang, Ming Zhao, Zhuo Liu, Ruineng Li, Tiexiang Ma, Prasanna Kumar Santhekadur   +9 more
wiley   +1 more source

Society for Endocrinology UK Guidance on the initial evaluation of a suspected difference or disorder of sex development (Revised 2021)

Clinical Endocrinology, Volume 95, Issue 6, Page 818-840, December 2021., 2021
Abstract It is paramount that any child or adolescent with a suspected difference or disorder of sex development (DSD) is assessed by an experienced clinician with adequate knowledge about the range of conditions associated with DSD and is discussed with the regional DSD service. In most cases, the paediatric endocrinologist within this service acts as
S. Faisal Ahmed, John Achermann, Julie Alderson, Naomi S. Crouch, Sue Elford, Ieuan A. Hughes, Nils Krone, Ruth McGowan, Talat Mushtaq, Stuart O’Toole, Leslie Perry, Martina E. Rodie, Mars Skae, Helen E. Turner   +13 more
wiley   +1 more source

Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells

Advanced Science, Volume 8, Issue 22, November 17, 2021., 2021
The progress of anti‐tumor immunity is reviewed. Recent findings of CD4+ T cell, CD8+ T cell, T cell exhaustion and B cell are provided. Several anti‐tumor immunotherapies based on different immune cells in these years and prospects of anti‐tumor immunotherapies are also discussed.
Yifan Xie, Feng Xie, Lei Zhang, Xiaoxue Zhou, Jun Huang, Fangwei Wang, Jin Jin, Long Zhang, Linghui Zeng, Fangfang Zhou   +9 more
wiley   +1 more source

Supplementary Material for: DHX37 and the implications in Disorders of Sex Development: an update review

, 2023
Background: DHX37 is an autosomal gene responsible for encoding a helicase from the DExD/H-box family that plays an essential role in ribosome biogenesis.
Guerra-Junior G. (4141957), Barros B.A. (17698665), Fabbri-Scallet H. (8106387), deOliveira F.R. (17698662), Maciel-Guerra A.T. (4682377), deMello M.P. (11834546), Guaragna M.S. (10216901)   +6 more
core   +1 more source

The genomics of phenotypically differentiated Asellus aquaticus cave, surface stream and lake ecotypes

Molecular Ecology, Volume 30, Issue 14, Page 3530-3547, July 2021., 2021
Abstract Organisms well suited for the study of ecotype formation have wide distribution ranges, where they adapt to multiple drastically different habitats repeatedly over space and time. Here we study such ecotypes in a Crustacean model, Asellus aquaticus, a commonly occurring isopod found in freshwater habitats as diverse as streams, caves and lakes.
Vid Bakovic, Maria Luisa Martin Cerezo, Andrey Höglund, Jesper Fogelholm, Rie Henriksen, Anders Hargeby, Dominic Wright   +6 more
wiley   +1 more source

Expanding DSD Phenotypes Associated with Variants in the DEAH-Box RNA Helicase DHX37

, 2021
International audienceMissense variants in the RNA-helicase DHX37 are associated with either 46,XY gonadal dysgenesis or 46,XY testicular regression syndrome (TRS).
Rezgoune, Djalila, Benelmadani, Yasmina, Rastari, Mandana, Satta, D, Totonchi, M, Simon, DS, Jauch, R, Ladjouze, Asmahane, Totonchi, Mehdi, Rastari, MA, Zidoune, H, Bignon-Topalovic, J, Sifi, Karima, Askari, Masomeh, Benelmadani, Y, Bignon-Topalovic, Joelle, Boukri, Asma, Satta, Dalila, Seresht-Ahmadi, M, Mcelreavey, Ken, Bashamboo, Anu, Boukri, A, Sifi, K, Tan, Daisylyn, Mazen, Inas, Askari, M, Simon, Dominique, Brauner, R, Brauner, Raja, Martinerie, LV, Mazen, I, Leger, J, Leger, Juliane, Ladjouze, A, Zidoune, Housna, Jauch, Ralf, Abadi, Noureddine, Abadi, N, McElreavey, K, Bashamboo,, A, Martinerie, Laetitia, TAN, DSY, Rezgoune, D, Seresht-Ahmadi, Mehrshad   +43 more
core   +1 more source