Results 11 to 20 of about 1,976,622 (262)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
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FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
On the accasion of the birthday of Mikhail Efimovich Zelzer
Сахарный диабет, 2010 Михаилу Ефимовичу Зельцеру, заслуженному деятелю науки Казахстана, академику Академии профилактической медицины Казахстана 23 сентября 2010 года исполнилось 80 лет.
Editorial team Diabetes Mellitus
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The new drug saxagliptin is now registrated in Russia
Сахарный диабет, 2010 23 ноября в Москве состоялся симпозиум, посвященный появлению в России нового препарата Онглиза (саксаглиптин) из группы ингибиторов дипептидилпептидазы-4 (ДПП-4).
Editorial team Diabetes Mellitus
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Diabetes 1.5: Ketone-Prone Diabetes [PDF]
Clinical Diabetes, 2015 Ketone-prone diabetes (KPD) is considered one of the atypical diabetes syndromes because its presentation can lead to misdiagnosis of the type of diabetes. Patients with KPD present in diabetic ketoacidosis (DKA), but once the DKA resolves, some patients can discontinue insulin and maintain adequate glycemic control with oral agents (1).
Safder, Sabina B., Mortada, Rami
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Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Russian Association of Endocrinologists about the introduction of Diabeton MR (60 mg tablets)
Сахарный диабет, 2011 Хорошо известный препарат Диабетон МВ 30 мг успешно применяется в России и мире для лечения больных сахарным диабетом 2 типа (СД2) с 2000 года. Доказанная эффективность и безопасность Диабетона МВ 30 мг послужила основанием для его широкого применения в ...
Editorial team Diabetes Mellitus
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Postgraduate Medical Journal, 1984 Involvement of the retinal microvascular vessels is an almost inevitable consequence of long standing diabetes. In the only large scale epidemiology study of a Caucasian population Klein et al. found some degree of retinopathy in up to 97% of patients with insulin dependent diabetes mellitus (IDDM) after about 15 years diabetes duration and in about 60%
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