Results 31 to 40 of about 2,035,272 (261)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Russian Association of Endocrinologists about the introduction of Diabeton MR (60 mg tablets)

open access: yesСахарный диабет, 2011
Хорошо известный препарат Диабетон МВ 30 мг успешно применяется в России и мире для лечения больных сахарным диабетом 2 типа (СД2) с 2000 года. Доказанная эффективность и безопасность Диабетона МВ 30 мг послужила основанием для его широкого применения в ...
Editorial team Diabetes Mellitus
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Russian Association of Endocrinologists reports commencement of Glimecomb clinical use

open access: yesСахарный диабет, 2011
Российская ассоциация эндокринологов информирует о начале применения в клинической практике препарата Глимекомб?. В настоящее время большинство пациентов с сахарным диабетом 2 типа получают комбинированную сахароснижающую терапию.
Editorial team Diabetes Mellitus
doaj   +1 more source

Diabetic Ketoacidosis Without Diabetes [PDF]

open access: yesThe Journal of Clinical Endocrinology & Metabolism, 2016
Type B insulin resistance syndrome is a rare disease that occurs due to the development of autoantibodies to the insulin receptor and can result in either severe insulin resistance and hyperglycemia or, conversely, hypoglycemia. Diabetes mellitus is often severe, usually transient, and poorly responsive to exogenous insulin. Diabetic ketoacidosis is an
Devina, Willard   +3 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Russian Association of Endocrinologists reports commencement of Amaril clinical use

open access: yesСахарный диабет, 2012
1 октября 2011 года в Санкт-Петербурге состоялось официальное представление нового препарата для лечения сахарного диабета 2 типа (СД2) ? Амарил? М (глимепирид+метформин). Препарат зарегистрирован в России 11 января 2011 года и в настоящее время доступен
Editorial team Diabetes Mellitus
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Expert committee on novel DPP-4 inhibitor TRADJENTA (linagliptin) in treatment of type 2 diabetes mellitus

open access: yesСахарный диабет, 2012
В Москве 11 апреля 2012 г. состоялость заседание экспертного совета по применению нового ингибитора дипептидилпептидазы-4 (ДПП-4) ТРАЖЕНТА (линаглиптин) в лечении сахарного диабета 2 типа (СД2).
Editorial team Diabetes Mellitus
doaj   +1 more source

ON DIABETES. [PDF]

open access: yesThe Lancet
n ...
openaire   +1 more source

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