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Postgraduate Medical Journal, 1984 Involvement of the retinal microvascular vessels is an almost inevitable consequence of long standing diabetes. In the only large scale epidemiology study of a Caucasian population Klein et al. found some degree of retinopathy in up to 97% of patients with insulin dependent diabetes mellitus (IDDM) after about 15 years diabetes duration and in about 60%
openaire +6 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Russian Association of Endocrinologists reports commencement of Glimecomb clinical use
Сахарный диабет, 2011 Российская ассоциация эндокринологов информирует о начале применения в клинической практике препарата Глимекомб?. В настоящее время большинство пациентов с сахарным диабетом 2 типа получают комбинированную сахароснижающую терапию.
Editorial team Diabetes Mellitus
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Russian Association of Endocrinologists reports commencement of Amaril clinical use
Сахарный диабет, 2012 1 октября 2011 года в Санкт-Петербурге состоялось официальное представление нового препарата для лечения сахарного диабета 2 типа (СД2) ? Амарил? М (глимепирид+метформин). Препарат зарегистрирован в России 11 января 2011 года и в настоящее время доступен
Editorial team Diabetes Mellitus
doaj +1 more source
The development of an innovative mobile phone app for type 1 diabetes alcohol education [PDF]
, 2013 Introduction Social media is being increasingly used to try and engage young people with their healthcare issues. However, most mobile diabetes applications (Apps) do not include personalised patient education, a key facet of diabetes self-management. We
Hill, J., Masding, M.G., Pulman, Andy
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Сахарный диабет, 2012 В Москве 11 апреля 2012 г. состоялость заседание экспертного совета по применению нового ингибитора дипептидилпептидазы-4 (ДПП-4) ТРАЖЕНТА (линаглиптин) в лечении сахарного диабета 2 типа (СД2).
Editorial team Diabetes Mellitus
doaj +1 more source
Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]
, 2015 A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M +28 more
core +4 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source