Results 81 to 90 of about 4,832,050 (357)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Results of ADVANCE stydy in type 2 diabetes patients

Сахарный диабет, 2007
Регулярное и постоянное назначение Нолипрела или Нолипрела форте ? фиксированной комбинации периндоприла и индапамида повышает выживаемость и снижает вероятность возникновения сердечно-сосудистых и почечных осложнений у больных сахарным диабетом 2 типа в
Editorial team Diabetes Mellitus
doaj   +1 more source

Assessment of Meal Anticipation for Improving Fully Automated Insulin Delivery in Adults With Type 1 Diabetes [PDF]

, 2023
José Garcia‐Tirado, Patricio Colmegna, Orianne Villard, Jenny L. Diaz, Rebeca Esquivel-Zuniga, Chaitanya L. K. Koravi, Charlotte L. Barnett, Mary C. Oliveri, Morgan Fuller, Sue A. Brown, Mark D. DeBoer, Marc D. Breton   +11 more
openalex   +1 more source

Differences in level of confidence in diabetes care between different groups of trainees: the TOPDOC diabetes study [PDF]

, 2014
Background There is an increasing prevalence of diabetes. Doctors in training, irrespective of specialty, will have patients with diabetes under their care.
George, Jyothis T, Jude, Edward B, Kar, Partha, McGrane, David J, McKay, Gerard, Price, Hermione C, Rozario, Kavithia S, Smith, Christopher J, Stratton, Irene M, Warriner, David, Wilmot, Emma G   +10 more
core   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

HYVET study has been preliminary finished because of significant decrease of stroke frequency by antihypertensive treatment of patiens older than 80 years

Сахарный диабет, 2007
Международное исследование, в котором изучались благоприятные эффекты антигипертензивного препарата у престарелых пациентов, было недавно остановлено в связи с тем, что исследователи получили данные о достоверном снижении общей смертности в группе ...
Editorial team Diabetes Mellitus
doaj   +1 more source

Deaths attributable to diabetes in the United States: comparison of data sources and estimation approaches [PDF]

, 2017
OBJECTIVE: The goal of this research was to identify the fraction of deaths attributable to diabetes in the United States. RESEARCH DESIGN AND METHODS: We estimated population attributable fractions (PAF) for cohorts aged 30±84 who were surveyed in the ...
Preston, Samuel, Stokes, Andrew
core   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Anniversary of METFORMIN: in 2007 - 50 years in use

Сахарный диабет, 2007
Метформин выдержал испытание временем. С момента его открытия прошло 50 лет, за это время показано множество положительных свойств метформина, доказана его эффективность как в лечении больных СД 2, так и в предотвращении прогрессирования нарушений ...
Editorial team Diabetes Mellitus
doaj   +1 more source

Cortical Plasticity and Interneuron Recruitment in Adolescents Born to Women with Gestational Diabetes Mellitus [PDF]

, 2021
Jago M. Van Dam, Mitchell R. Goldsworthy, William M. Hague, Suzette Coat, Julia B. Pitcher   +4 more
openalex   +1 more source