Results 71 to 80 of about 441,381 (262)
SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition
Advanced Science, EarlyView.Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo +14 more
wiley +1 more source
Zaporožskij Medicinskij ŽurnalAim. To evaluate left ventricular myocardial structural remodeling in experimental type 1 diabetes mellitus (T1DM) and to assess the effects of L-arginine and N-acetyl-L-cysteine. Materials and methods. The study involved 47 male Wistar rats.
M. I. Isachenko , Yu. M. Kolesnyk
doaj +1 more source
THE ROLE OF NITROGEN OXIDE AND NITROSATIVE STRESS IN BURN WOUND HEALING IN DIABETES MELLITUS
Медична наука України, 2019 Relevance. The risk of developing of diabetic foot ulcers is 25% over the lifetime of patients with diabetes mellitus. Inhibition of wound healing is associated with impaired macrophage polarization, decreased bioavailability of growth factors, enhanced ...
O.I. Myronenko, L.V. Natrus, T.I. Panova
doaj +1 more source
Advanced Science, EarlyView.Epsilon‐near‐zero (ENZ) silicon carbide enables a selective far‐infrared emitter spectrally aligned with the human skin window around 10 µm for wavelength‐matched thermal therapy. In 25 within‐subject trials (50 hands) monitored by laser speckle contrast imaging, SiC increases blood perfusion by 30.2% versus a broadband graphite emitter while ...
Wen‐Teng Yao +3 more
wiley +1 more source
Frontiers in EndocrinologyThe increasing global prevalence of diabetes mellitus and its complications continues to encourage exploration of novel molecular mechanisms for their prevention and treatment.
Guangyang Yin +5 more
doaj +1 more source
Remodeling of adipose tissue at experimental diabetes mellitus
Zaporožskij Medicinskij Žurnal, 2013 Introduction Diabetes mellitus (DM) type 1 is chronіc disease whith progressive selective destruction of β- cells pancreatic islets (of Langerhans) and whith development of absolute insulin failure.
O. A. Konovalova, A. M. Kamyshnyi
doaj +1 more source
Advanced Science, EarlyView.A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley +1 more source
مجله دانشگاه علوم پزشکی گرگان, 2021 Background and Objective: Diabetes mellitus is one of the most common metabolic and global health threats. The gene needed for the development of the TBX20 gene is the fusion of the gene, and the defect in the sequence and expression of this gene also ...
Zeynab Alinezhad +2 more
doaj
Revista Peruana de Medicina Experimental y Salud Pública, 2014 Objectives. To determine if the lyophilized aqueous extract of Geranium ayavacense (Pasuchaca) has any effect on glycemia in rats with experimental diabetes mellitus. Materials and methods. Experimental diabetes was induced with alloxan. Rats included in
José Aranda-Ventura +3 more
doaj +1 more source
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source