Results 111 to 120 of about 1,232,473 (312)

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Khat Chewing and Type 2 Diabetes Mellitus

Diabetes, Metabolic Syndrome and Obesity, 2020
Mohammed Badedi,1 Hussain Darraj,1 Abdulrahman Hummadi,1 Abdullah Najmi,2 Yahiya Solan,1 Ibrahim Zakry,1 Abdullah Khawaji,1 Sayedah Zaylai,1 Norah Rajeh,1 Hassan Alhafaf,1 Wali Hakami,1 Awaji Bakkari,1 Maryam Kriry,1 Abdulraheem Dagreri,1 Ebrahim Haddad1
Badedi M, Darraj H, Hummadi A, Najmi A, Solan Y, Zakry I, Khawaji A, Zaylai S, Rajeh N, Alhafaf H, Hakami W, Bakkari A, Kriry M, Dagreri A, Haddad E   +14 more
doaj  

Glycemic Variability and Type 2 Diabetes Mellitus [PDF]

Applied Medical Informatics, 2013
Aim: The purpose of the present study was to quantify glucose variability in type 2 diabetic patients and establishing relationship with cardiometabolic parameters and type of glucose-lowering treatment.
Nicolae HÂNCU, Ştefan ŢIGAN, Mihaela GRIBOVSCHI   +2 more
doaj  

Preventive pharmacotherapy in type 2 diabetes mellitus

Indian Journal of Endocrinology and Metabolism, 2012
Over the last few decades certain demographic changes have been observed worldwide, which have led to an increase in the prevalence of chronic non-communicable diseases.
Neeraj Choudhary, Sanjay Kalra, Ambika Gopalakrishnan Unnikrishnan, T P Ajish   +3 more
doaj   +1 more source

Low serum cartonectin/CTRP3 concentrations in newly diagnosed Type 2 Diabetes Mellitus : in vivo regulation of Cartonectin by glucose [PDF]

, 2014
Objectives: Cartonectin is a novel adipokine of the C1q complement/TNF-related protein (CTRP) superfamily, with glucose lowering effects, anti-inflammatory and cardio-protective properties. We sought to investigate circulating cartonectin concentrations
Jing Chen, Hu Jiamiao, Ramanjaneya Manjunath, Bee K. Tan, Hu, Jiamiao, Zhang, Manman, Bai Bo, Tan, Bee K., Manman Zhang, Tan Bee K., Bee K Tan, Ban, Bo, Bai, Bo, Bo Ban, Ban Bo, Chen Jing, Manjunath Ramanjaneya, Bo Bai, Zhang Manman, Jiamiao Hu, Ramanjaneya, Manjunath, Chen, Jing, Tan, Bee K   +22 more
core   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes:rationale and design of the epidemiological studies within the IMI DIRECT Consortium [PDF]

, 2014
Aims/hypothesisThe DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe.
Rauh, S., Jablonka, B, Bernd Jablonka, Teare, Harriet J A, Frost, G.S., Ridderstråle, Martin, Herrgard, S., Hattersley, A, McDonald, T. J., Sanna Herrgård, Franks, Paul W., Bell, J., Cederberg, Henna, Hansen, TH, Andrea Mari, Pedersen, Oluf, Siloaho, Maritta, Mark Walker, Pearson, Ewan; id_orcid, Pearson, Ewan, Heymans, Martijn W., Perry, MH, Hansen, T.H., Rauh, S, Veikko Koivisto, Ridderstråle, Martin,, McDonald, T.J., Brunak, Søren, Cederberg, H., Barnett, A, Heymans, MartijnW., Frost, G, Vestergaard, H., Hattersley, Andrew T., Franks, P.W., Perry, Mandy, Laakso, M., Consortium, Direct, Paul W. Franks, Barnett, A., Heggie, A., Hansen, T., Thorand, Barbara, Heymans, MW, Siloaho, M., null null, Maritta Siloaho, Koivula, RW, Henrik Vestergaard, Hansen, Tue H., Alison Heggie, Lund University., Teare, Harriet J. A., Hansen, Tue H, Ewan Pearson, Ruetten, H, Hansen, T, Ramneek Gupta, Dekker, Jacqueline M, Rutters, Femke, Walker, M, Koopman, Anitra D, Tim J. McDonald, Barnett, Anna, Pearson, E, Koopman, AD, Koivula, R. W., Pearson, E., Koivula, Robert W., Heggie, Alison, McDonald, TJ, Koivula, Robert, Frost, G., Franks, PaulW., Rutters, F., Koopman, A. D., Perry, M.H., Heymans, M.W., Heggie, A, Ruetten, Hartmut, Simone Rauh, DIRECT Consortium (), Dekker, JM, Perry, MandyH., Hattersley, A., Koivula, R.W., Pearson, E. R., Franks, Paul, Herrgård, S, Franks, P. W., Vestergaard, H, Tue H. Hansen, Heymans, M. W., Koopman, AnitraD., Frost, Gary, Markku Laakso, Gary Frost, Gupta, Ramneek, Bell, J, Koopman, Anitra, Herrgård, Sanna, Teare, HJA, Dekker, Jacqueline M., Hattersley, Andrew, Hansen, Tue Haldor, Walker, M., Torben Hansen, Ridderstråle, M, Bell, Jimmy, Thorand, B, Brunak, S., Heymans, Martijn W, Søren Brunak, Laakso, M, Koopman, Anitra D., Koivisto, V., Mari, Andrea, Perry, Mandy H, Ridderstrale, M., Femke Rutters, Brunak, Soren, Pedersen, O., Hansen, Torben, Jacqueline M. Dekker, Perry, M. H., Gupta, R, Mari, A., Barbara Thorand, Teare, H. J. A., Koivisto, V, Mari, A, Dekker, JacquelineM., Koivula, RobertW., Walker, Mark, Oluf Pedersen, Franks, Paul,, Dekker, J.M., Siloaho, M, Ruetten, H., Cederberg, H, Koopman, A.D., Teare, HarrietJ.A., Pedersen, O, Dekker, J. M., Mandy H. Perry, Anitra D. Koopman, Martijn W. Heymans, Anna Barnett, Koivisto, Veikko, Laakso, Markku, Teare, H.J.A., Hansen, T. H., McDonald, TimJ., Henna Cederberg, Rauh, Simone, McDonald, Tim J, Gupta, R., Harriet J. A. Teare, Teare, H.J., Hartmut Ruetten, Jablonka, Bernd, Brunak, S, Bell, J.D., Andrew Hattersley, Franks, PW, Rutters, F, Vestergaard, Henrik, Hansen, T. V. O., Martin Ridderstråle, Robert W. Koivula, Thorand, B., Jablonka, B., Jimmy Bell, Koivula, Robert,, McDonald, Tim J., Perry, Mandy H., McDonald, Timothy J.   +176 more
core   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

Dietary factors and Type 2 diabetes in the Middle East : what is the evidence for an association? - A systematic review. [PDF]

, 2013
This review aims to search and summarise the available evidence on the association between dietary factors and type 2 diabetes mellitus (T2DM) in Middle Eastern populations, where diabetes prevalence is among the highest in the world.
Karen Rees, Sudhesh Kumar, Nasser Al-Daghri, Al-Daghri, Nasser M., Lena Al-Khudairy, Stranges, Saverio, Al-Khudairy, Lena, Saverio Stranges, Rees, Karen, Kumar, Sudhesh, Al-Daghri, Nasser   +10 more
core   +1 more source