Results 41 to 50 of about 1,541,306 (306)

Identification of five genetic variants as novel determinants of type 2 diabetes mellitus in Japanese by exome-wide association studies [PDF]

, 2017
We performed exome-wide association studies to identify single nucleotide polymorphisms that either influence fasting plasma glucose level or blood hemoglobin A1c content or confer susceptibility to type 2 diabetes mellitus in Japanese.
Arai Tomio, Fujimaki Tetsuo, Fujiwara Yoshinori, Horibe Hideki, Kato Kimihiko, Kawai Hisashi, Mori Seijiro, Muramatsu Masaaki, Obuchi Shuichi, Oguri Mitsutoshi, Sakuma Jun, Sawabe Motoji, Shinkai Shoji, Takeuchi Ichiro, Tanaka Masashi, Taniguchi Yu, Yamada Yoshiji, Yasukochi Yoshiki, 佐久間 淳   +18 more
core   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Social representations of feeding people with type-2 diabetes mellitus [PDF]

, 2016
The aim of this study was to analyze the social representations of the diets 34 patients of the Brazilian public primary care service diagnosed with type- 2 diabetes mellitus, according to how they represent their identity.
Amorim, Maria Marta Amancio, Gazzinelli, Maria Flávia, Ramos, Natália   +2 more
core   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

The Effect of Family History, Physical Activity, and Overweight on Type 2 Diabetes Mellitus in Elderly Iin Padang Bulan Community Health Center, Medan [PDF]

, 2018
Background: Diabetes mellitus is a global public health problem. In Indonesia, the prevalence of diabetes mellitus increased from 1.1% in 2007 to 2.1% in 2013. Prevalence of diabetes mellitus in North Sumatera was 2.3%. Medan ranked second highest with 2.
Nurmaini, N. (Nurmaini), Sipayung, R. (Ronika), Siregar, F. A. (Fazidah)   +2 more
core  

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Evaluasi Kerasionalan Pengobatan Diabetes Melitus Tipe 2 Pada Pasien Rawat Inap Di Rumah Sakit Bhakti Wira Tamtama Semarang Tahun 2006 [PDF]

, 2007
ASTRACTDiabetes melitus is metabolic disease characterized hiperglikemia that caused disparity of insulin secretion, insulin activity or both. WHO had predicted there were increasing of diabetes mellitus patients in next time, included in Indonesia. This
andayani, T. M. (tri), arifin, I. (ibrahim), prasetyaningrum, E. (erna)   +2 more
core  

Complications of the Type 2 Diabetes Mellitus [PDF]

Current Cardiology Reviews, 2021
Farmaki, P., Damaskos, C., Garmpis, N., Garmpi, A., Savvanis, S., Diamantis, E.   +5 more
openaire   +3 more sources