Results 41 to 50 of about 1,505,406 (304)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Identification of five genetic variants as novel determinants of type 2 diabetes mellitus in Japanese by exome-wide association studies [PDF]

, 2017
We performed exome-wide association studies to identify single nucleotide polymorphisms that either influence fasting plasma glucose level or blood hemoglobin A1c content or confer susceptibility to type 2 diabetes mellitus in Japanese.
Arai Tomio, Fujimaki Tetsuo, Fujiwara Yoshinori, Horibe Hideki, Kato Kimihiko, Kawai Hisashi, Mori Seijiro, Muramatsu Masaaki, Obuchi Shuichi, Oguri Mitsutoshi, Sakuma Jun, Sawabe Motoji, Shinkai Shoji, Takeuchi Ichiro, Tanaka Masashi, Taniguchi Yu, Yamada Yoshiji, Yasukochi Yoshiki, 佐久間 淳   +18 more
core   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

The Effect of Family History, Physical Activity, and Overweight on Type 2 Diabetes Mellitus in Elderly Iin Padang Bulan Community Health Center, Medan [PDF]

, 2018
Background: Diabetes mellitus is a global public health problem. In Indonesia, the prevalence of diabetes mellitus increased from 1.1% in 2007 to 2.1% in 2013. Prevalence of diabetes mellitus in North Sumatera was 2.3%. Medan ranked second highest with 2.
Nurmaini, N. (Nurmaini), Sipayung, R. (Ronika), Siregar, F. A. (Fazidah)   +2 more
core  

Social representations of feeding people with type-2 diabetes mellitus [PDF]

, 2016
The aim of this study was to analyze the social representations of the diets 34 patients of the Brazilian public primary care service diagnosed with type- 2 diabetes mellitus, according to how they represent their identity.
Amorim, Maria Marta Amancio, Gazzinelli, Maria Flávia, Ramos, Natália   +2 more
core   +1 more source

Preventing Type 2 Diabetes Mellitus [PDF]

The Journal of the American Board of Family Medicine, 2005
Type 2 diabetes is a serious, costly, and increasingly common disease. Several conditions commonly seen in family medicine settings confer increased risk of developing diabetes. Among these conditions are impaired glucose tolerance, impaired fasting glucose, obesity, gestational diabetes, hypertension, hyperlipidemia, and menopause. We here present the
Charlton Wilson, Jeff Curtis
openaire   +2 more sources

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Simvastatin Use in Patients with Type 2 Diabetes Mellitus: The Effects on Oxidative Stress

Oman Medical Journal, 2015
Objectives: Studies have shown that people with type 2 diabetes mellitus (T2DM)may develop atherosclerosis due to the disturbance in oxidative control and progressive dyslipidemia.
Mohammad A. Abdelhussein, Ammar R. M. Rudha, Dina A. Jamil, Hayder A. Al-Aubaidy   +3 more
doaj   +1 more source

Type 2 Diabetes Mellitus and Pulmonary Tuberculosis

Scripta Score Scientific Medical Journal, 2023
Background: Type 2 diabetes mellitus is a major health problem worldwide. In spite of the high incidence and prevalence, T2DM is often associated with pulmonary tuberculosis infection which is also a world health burden.
Peggy Liberty, Maggie Liberty
doaj   +1 more source