Results 51 to 60 of about 30,954,665 (307)

Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin [PDF]

, 2010
OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy.
Rabbani, Naila, D. Zehnder, A. Ceriello, P. J. Thornalley, N. Rabbani, Zehnder, Daniel, Chittari, Madhu Varma, C. W. Bodmer, Bodmer, Charles W., Ceriello, Antonio, M. V. Chittari, Thornalley, Paul J.   +11 more
core   +1 more source

Cytogenetic study of type 2 diabetes mellitus

Wasit Journal for Pure Sciences, 2022
Type 2 of diabetic mellitus (DM) is characterized by chronic hyperglycemia with abnormalities of fat and protein metabolism resulting from defects in insulin secretion, insulin action or both.
Zafir Hassan Ghali , Noor Jamal Hussein
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Simvastatin Use in Patients with Type 2 Diabetes Mellitus: The Effects on Oxidative Stress

Oman Medical Journal, 2015
Objectives: Studies have shown that people with type 2 diabetes mellitus (T2DM)may develop atherosclerosis due to the disturbance in oxidative control and progressive dyslipidemia.
Mohammad A. Abdelhussein, Ammar R. M. Rudha, Dina A. Jamil, Hayder A. Al-Aubaidy   +3 more
doaj   +1 more source

Type 2 diabetes mellitus and bone [PDF]

Journal of Internal Medicine, 2018
AbstractType 2 diabetes (T2DM) is a rapidly growing public health problem. It is associated with an increased risk of fracture, particularly of the hip, despite normal or high bone mineral density. Longer duration of disease and poor glycaemic control are both associated with higher fracture risk. The factors underlying increased fracture risk have not
openaire   +2 more sources

Diabetes mellitus type 2 in urban Ghana: characteristics and associated factors. [PDF]

, 2012
BACKGROUND: Sub-Saharan Africa faces a rapid spread of diabetes mellitus type 2 (DM2) but its potentially specific characteristics are inadequately defined.
Spranger, J, Micah Frank, Bedu-Addo George, Mockenhaupt Frank P, Karl-Johann Terpe, Bedu-Addo, G, Ekkehart Dietz, Frank Micah, Amoako, YA, Ina Danquah, van der Giet, M, van der Giet Markus, Awuku Yaw A, Dietz, E, Micah, F, Yaw A Amoako, Terpe, KJ, Awuku, YA, Danquah, I, Mockenhaupt, FP, Danquah Ina, Joachim Spranger, Amoako Yaw A, George Bedu-Addo, Terpe Karl-Johann, Spranger Joachim, Markus van der Giet, Frank P Mockenhaupt, Dietz Ekkehart, Yaw A Awuku   +29 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians : ADCY5 and GLIS3 variants may predispose to type 2 diabetes [PDF]

, 2011
Background: The Meta-Analysis of Glucose and Insulin related traits Consortium (MAGIC) recently identified 16 loci robustly associated with fasting glucose, some of which were also associated with type 2 diabetes.
Hydrie, MZI, Simon D. Rees, Abdul Basit, Hydrie M. Zafar I., Shera, A. Samad, Barnett, Anthony, Shera A. Samad, M. Zafar I. Hydrie, Basit, A, Basit Abdul, Anthony H Barnett, J. Paul O'Hare, Kumar Sudhesh, Sudhesh Kumar, Rees, Simon D., Rees, Simon, Kelly, M. Ann, Shera, AS, Kelly, Marilyn, A Samad Shera, Basit, Abdul, O'Hare J. Paul, Rees Simon D., J Paul O'Hare, A. Samad Shera, O'Hare, JP, Anthony H. Barnett, Kumar, Sudhesh, M. Ann Kelly, Kelly M. Ann, Hydrie, M. Zafar I., Simon D Rees, Barnett, A. H., Kumar, S, M Zafar I Hydrie, O'Hare, J. Paul, Barnett Anthony H., M Ann Kelly   +37 more
core   +2 more sources

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source