Results 101 to 110 of about 28,141,875 (293)

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Physical education classes for students with type I diabetes mellitus [PDF]

Физическое воспитание и студенческий спорт
Type I diabetes mellitus is a chronic disease that requires constant monitoring of blood glucose levels and daily insulin administration. In recent years, there has been an increase in the number of cases, especially among young people and students.
Tarasov, Arkady Yu.
doaj   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Knowledge and Practices in Diabetic Foot Ulcer Prevention Among Patients with Diabetes Mellitus in Gauteng, South Africa

Diabetology
Background: Patients with diabetes mellitus are at increased risk of foot ulcerations. Prevention and timeous treatment of diabetic foot ulcer requires a multidisciplinary team, including patients and healthcare workers.
Tshifhiwa Mukheli, Tshepo P. Mokoena, Shingirai B. Kagodora, Thifhelimbilu E. Luvhengo   +3 more
doaj   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

THE IMPACT OF RISK FACTORS AND INSULIN ADMININSTRATION METHOD ON THE CONDITION OF THE RETINA IN CHILDREN WITH TYPE I DIABETES MELLITUS

Российский офтальмологический журнал, 2018
Purpose: to assess the impact of risk factors and the method of insulin administration on the retina of children with type 1 diabetes. Materials and methods.
A. N. Samoylov, T. R. Khaibrakhmanov, G. A. Fazleeva, P. A. Samoylova, M. A. Fazleeva   +4 more
doaj   +1 more source

Diabetes mellitus in pregnancy : a clinical and public health problem [PDF]

Diabetes is the most frequently encountered endocrine disorder in pregnancy and is associated with adverse outcomes. Despite the urgent need for interventions to improve the outcomes for pregnancies complicated with diabetes, and the consistent ...
Wahabi, Haifa A. A.
core  

Dietary factors and Type 2 diabetes in the Middle East : what is the evidence for an association? - A systematic review. [PDF]

, 2013
This review aims to search and summarise the available evidence on the association between dietary factors and type 2 diabetes mellitus (T2DM) in Middle Eastern populations, where diabetes prevalence is among the highest in the world.
Karen Rees, Sudhesh Kumar, Nasser Al-Daghri, Al-Daghri, Nasser M., Lena Al-Khudairy, Stranges, Saverio, Al-Khudairy, Lena, Saverio Stranges, Rees, Karen, Kumar, Sudhesh, Al-Daghri, Nasser   +10 more
core   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source