Results 111 to 120 of about 28,141,875 (293)

Cognitive and brain function in adults with Type 1 diabetes mellitus : is there evidence of accelerated ageing? [PDF]

, 2013
The physical complications of Type 1 diabetes mellitus (T1DM) have been understood as an accelerated ageing process (Morley, 2008). Do people with T1DM also experience accelerated cognitive and brain ageing?
Johnston, Harriet N.
core   +2 more sources

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Percepções das pessoas com diabetes mellitus acerca da doença e das complicações crônicas [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Enfermagem, Florianópolis, 2014.O diabetes mellitus traz mudanças importantes na vida das pessoas, pois requer cuidados ...
Campos, Thais Silva Pereira
core  

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Polymorphisms of the _ENPP1_ gene are not associated with type 2 diabetes or obesity in the Chinese Han population [PDF]

, 2008
*Objective:* Type 2 Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia and with a major feature of insulin resistance. Genetic association studies have suggested that _ENPP1_ might play a potential role in susceptibility to ...
Daizhan Zhou, Sheng Li, Yun Liu, He Xu, Lin He, Zuofeng Zhang, Zhuo Chen, Simin Liu, Lan Yu, Teng Zhao, Guoyin Feng, Di Zhang   +11 more
core  

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

The association between serum gamma glutamyltransferase levels and microalbuminuria in Type 2 diabetic patients

Global Journal of Medicine and Public Health
Background and Objectives Diabetic nephropathy is the major cause of chronic kidney disease and end stage renal disease in developing countries. Almost one third of the diabetic patients develop diabetic nephropathy in their life time. So it
C.K.Vijayasamundeeswari, R. Sudha
doaj  

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Иммуноцитогенетическая характеристика детей, страдающих сахарным диабетом I типа

Фактори експериментальної еволюції організмів, 2014
Aims. The purpose of our study was to assess associative ability of acrocentric chromosomes (AC) in the peripheral blood lymphocytes of patients with type I diabetes mellitus. Methods.
В. И. Ковалева, Е. А. Будрейко, С. А. Чумак   +2 more
doaj  

Insulin Analogues (Insulin Detemir and Insulin Aspart) Versus Traditional Human Insulins (NPH Insulin Regular Human Insulin) in Basal Bolus Therapy for Patients with Type-I Diabetes Mellitus

Pakistan Armed Forces Medical Journal
Objective: To compare the effect of Insulin analogues (Insulin Detemir and Insulin Aspart) versus Traditional Human Insulins (NPH Insulin Regular Human Insulin) in basal bolus therapy for patients with Type-I Diabetes Mellitus.
Muhammad Hamza Zaheer, Muhammad Adnan Manzar, Bilal Ahmed, Roshaan Tahir, Muhammad Hamza Qureshi, Shawnze Akhtar   +5 more
doaj   +1 more source