Results 121 to 130 of about 1,198,108 (334)

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

From Cell‐Free Transcriptomes to Single‐Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization

Advanced Science, EarlyView.
CellFreeGMF traces plasma cfRNA to likely originating cell types by integrating single‐cell atlases with graph‐regularized matrix factorization. The method decomposes cfRNA profiles into sample–cell contributions to reconstruct pseudo single‐cell expression.
Wenxiang Zhang, Wenjing Zhang, Hang Wei, Shiyan Liu, Junliang Shang, Weijie Gong, Hanwen Cheng, Xiujuan Lei, Yuhui Kou, Baoguo Jiang   +9 more
wiley   +1 more source

The Management of Diabetes in Children [PDF]

, 1966
I think the time will come when we will all agree that diabetes mellitus is indeed the most common endocrinopathy, and that if we live long enough, at least 25% of the people in this room will develop diabetes.
Danowski, Thaddeus S.
core   +1 more source

Large‐Scale Quantitative Morphometry of Platelet α‐Granules via SIM Super‐Resolution Microscopy for Cancer Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Blood‐based liquid biopsies hold transformative potential for non‐invasive cancer management, but current approaches relying on rare circulating tumor components limit their broad clinical utility. Platelets, abundant in blood and mediating diverse cancer‐associated responses, represent a compelling yet largely unexplored alternative.
Yan Ma, Huan Deng, Zelin Liu, Simei Zhong, Liangliang Wang, Mu He, Ning Jing, Lihua Dai, Yuzhen Basang, Xiao‐Yu Hu, Changyi Zhang, Huimin Zeng, Haoren Shao, Zhe Yang, Shanshan Zhao, Xiaohai Hu, Chuanjie Zhang, Xiaowei Wu, Jing Xu, Shaoqun Zeng, Jing Yuan, Qiang Li, Ziwei Qu, Zhenya Hong, Lingjuan Chen, Hanhua Dong, Jia Guo, Zhiqiang Han, Yu‐Hui Zhang   +28 more
wiley   +1 more source

Peculiarities of course of the urolithiasis disease in patients with a solitary kidney and concomitant diabetes mellitus type II

Клінічна хірургія, 2019
Objective. To analyze the cases histories of urolithiasis disease and its course peculiarities in patients with a solitary kidney, unilateral urolithiasis and concomitant diabetes mellitus type II. Маterials and methods.
D. I. Кuprin, А. I. Boyko, N. О. Saidakova, А. О. Gubar   +3 more
doaj   +1 more source

Pediatric Type II Diabetes Mellitus: Examining the Upward Trend [PDF]

, 2018
In recent years, there has been a significant increase in pediatric onset of type II diabetes. This paper will examine elements contributing to this trend.
Foering, Allison
core   +1 more source

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

Intervention of Natural Microalgal Bioactives on Type 2 Diabetes: Integrated Scientometric Mapping and Cellular Efficacy Studies

Phycology
Type 2 diabetes mellitus (T2DM) is recognized as a multifactorial health disorder associated with various complications. This paper presents a bibliometric analysis of type 2 diabetes mellitus and natural active substances.
Ran Chen, Hongxiang Zhao, Shilin Wu, Ning Yang, Zhen Zhang, Kun Li, Jingyun Chen, Pei Wang, Xiaojun Liu, Rongqing Zhang   +9 more
doaj   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Assessment Of Depressive Symptoms In Adolescents With Diabetes Mellitus Type I

Kufa Journal for Nursing Sciences, 2013
Objective: Assess depressive symptoms in adolescents with diabetes type I. Methodology: A descriptive study was conducted in two centers for endocrinology and diabetes in Baghdad city (50) of adolescents were selected; with diabetes mellitus type1 in center for endocrinology and diabetes centers for endocrinology and diabetes in rusafa and center for ...
openaire   +2 more sources