Results 241 to 250 of about 917,880 (323)
Animal Models and Experimental Medicine, EarlyView.The electrophysiological change in neurons might contribute to the cognitive and emotional changes during pregnancy. Abstract Background Pregnancy affects learning and memory in women. Thus, to investigate the effects of pregnancy, the authors examined the brain electrophysiology of pregnant mice.
Xuefan Bin, Huijuan Luo
wiley +1 more source
Biaryl Phosphates and Phosphonates as Selective Inhibitors of the Transcription Factor STAT4
Angewandte Chemie, EarlyView.The transcription factor STAT4 is a therapeutic target for autoimmune diseases. Here, para‐biaryl phosphates and phosphonates are presented as the first small‐molecule inhibitors of STAT4. The phosphonate Stafori‐1 selectively stabilizes STAT4 against thermal denaturation in cell lysates, and its cell‐permeable prodrug Pomstafori‐1 selectively inhibits
Nadiya Brovchenko +7 more
wiley +2 more sources
On the Inheritance of Diabetes Mellitus
, 1933 Gregory Pincus, Priscilla White
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Animal Models and Experimental Medicine, EarlyView.Though the Leprdb/db mouse is a common and well‐studied model of type II diabetes mellitus, there are a few specific guidelines for its husbandry, and wound complications are common. We present a modified husbandry approach for the Leprdb/db mouse that includes increased cage size, decreased housing density, and more frequent cage changes.
May Barakat +6 more
wiley +1 more source
Clinical Relevance of ‘Cap’ and ‘Track’ Development after Recent Small Subcortical Infarct
Annals of Neurology, EarlyView.Objective After a recent small subcortical infarct (RSSI), some patients develop perilesional or remote hyperintensities (‘caps/tracks’) to the index infarct on T2/FLAIR MRI. However, their clinical relevance remains unclear. We investigated the clinicoradiological correlates of ‘caps/tracks’, and their impact on long‐term outcomes following RSSI ...
Yajun Cheng +24 more
wiley +1 more source
RETENTION OF PROTEIN DURING DIET REDUCTION TO RELIEVE THE GLYCOSURIA IN DIABETES MELLITUS [PDF]
, 1921 R. L. Fenlon
openalex +1 more source
Annals of Neurology, EarlyView.Objectives Intravenous thrombolysis (IVT) is contraindicated for acute ischemic stroke (AIS) patients taking direct oral anticoagulants (DOACs) within 48 hours before index stroke. Limited data exist on off‐label use of IVT for these patients. We compared the safety and outcomes of IVT in AIS patients with DOAC treatment and patients with no OAC before
Marius Matusevicius +11 more
wiley +1 more source