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Experimental Approaches to Diabetes Mellitus

The Eurasian Journal of Medicine, 2023
One of the most common health problems today, diabetes is a serious, chronic, and complex disease characterized by high blood glucose levels. Nowadays, experimental diabetes models are being developed to study existing diabetes in depth, to improve diabetes medications, or to develop new medications.
Muhammed Yayla, Damla Binnetoğlu
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Experimental Diabetes Mellitus in Different Animal Models [PDF]

Journal of Diabetes Research, 2016
Animal models have historically played a critical role in the exploration and characterization of disease pathophysiology and target identification and in the evaluation of novel therapeutic agents and treatments in vivo. Diabetes mellitus disease, commonly known as diabetes, is a group of metabolic disorders characterized by high blood glucose levels ...
Amin Al-awar, Krisztina Kupai, Médea Veszelka, Gergő Szűcs, Zouhair Attieh, Zsolt Murlasits, Szilvia Török, Anikó Pósa, Csaba Varga   +8 more
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The latest progression of N6-methyladenosine (m⁶A) RNA modification in diabetes mellitus and diabetic complications. [PDF]

Front Endocrinol (Lausanne)
The increasing global prevalence of diabetes mellitus and its complications continues to encourage exploration of novel molecular mechanisms for their prevention and treatment.
Yin G, Hong J, Shan G, Xu C, Li B, Yang D.   +5 more
europepmc   +2 more sources

Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway

Frontiers in Cell and Developmental Biology, 2020
Liraglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has been demonstrated to alleviate non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanism has not been fully elucidated.
Yunyun Fang, Linlin Ji, Chaoyu Zhu, Yuanyuan Xiao, Jingjing Zhang, Junxi Lu, Jun Yin, Jun Yin, Li Wei   +8 more
doaj   +1 more source

Insulin-like growth factors and their carrier proteins in kidneys of rats with experimental diabetes, malignant tumor, and their combination

Бюллетень сибирской медицины, 2022
Persistent hyperglycemia resulting from diabetes mellitus causes microvascular lesions and long-term diabetic complications, such as nephropathy.The aim of the study was to analyze the levels of insulin-like growth factors (IGFs), their carrier proteins (
E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, L. K. Trepitaki, N. D. Cheryarina, I. M. Kotieva, M. I. Morozova   +9 more
doaj   +1 more source

Vascular Reactivity in Experimental Diabetes Mellitus [PDF]

Circulation Research, 1964
Vascular reactivity was examined in vessels of the perfused hindquarters of alloxan diabetic and control rats. A significant increase was noted in responsiveness of the diabetic animals to intra-arterial injection of epinephrine, norepinephrine, and synthetic angiotensin.
MICHAEL J. BRODY, ROBERT L. DIXON, Richard A. Shaffer   +2 more
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Avaliação de parâmetros de cicatrização no cólon de ratos diabéticos sem agressão cirúrgica [PDF]

Acta Cirúrgica Brasileira, 2004
OBJETIVO: Existem poucos estudos na literatura utilizando parâmetros de cicatrização em animais diabéticos antes da agressão cirúrgica e nenhum estudo no colon.
Erika Veruska Paiva Ortolan, César Tadeu Spadella, José Lúcio Martins Machado, Shoiti Kobayasi   +3 more
doaj   +1 more source

The Effect of Health Education on Knowledge of The Prevention of Diabetes Mellitus

Babali Nursing Research, 2022
Introduction: Diabetes mellitus (DM) is a lifelong disease that cannot be cured permanently, which according to WHO estimates the number of people with diabetes will be the main cause of 7 deaths in 2030.
Dewi Wijayanti
doaj   +1 more source

Pancreatic islet isolation by mechanical-enzymatic separation, stationary collagenase digestion and dextran discontinuous density gradient purification: experimental study in dogs Isolamento das ilhotas pancreáticas pela separação mecânica-enzimática digestão estacionária com colagenase e purificação com gradiente de densidade descontínua de dextran: estudo experimental em cães

Acta Cirúrgica Brasileira, 2002
The prospects for allotransplantation of pancreatic islets in man depend on the development of methods that provide sufficient quantities of pancreatic islets from a single donor, which are capable, when transplanted, of achieve the normalization of ...
Jaques Waisberg, Heloísa Prado Soares, Luís Gustavo Altieri, Osíris Ramaciotti, Manlio Basilio Speranzini   +4 more
doaj   +1 more source

Aminoguanidina reduz o estresse oxidativo e as alterações estruturais pulmonares em diabetes mellitus experimental Aminoguanidine reduces oxidative stress and structural lung changes in experimental diabetes mellitus

Jornal Brasileiro de Pneumologia, 2010
Avaliamos o efeito da aminoguanidina sobre o estresse oxidativo pulmonar e a estrutura pulmonar em um modelo experimental de diabetes mellitus.
Fabio Cangeri Di Naso, Luiz Alberto Forgiarini Junior, Luiz Felipe Forgiarini, Marilene Porawski, Alexandre Simões Dias, Norma Anair Possa Marroni   +5 more
doaj   +1 more source