Results 141 to 150 of about 1,956,253 (381)

A non-healing corneal ulcer as the presenting feature of type 1 diabetes mellitus: a case report [PDF]

, 2011
Alexander S Ioannidis, Sofia L Zagora, Alfred W Wechsler   +2 more
openalex   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Neglected-Noncompliant Type 1 Diabetes Mellitus with Complications

Jurnal Kesehatan Andalas, 2012
AbstrakDiabetes mellitus (DM) tipe 1 merupakan kelainan sistemik akibat terjadinya gangguan metabolisme glukosayang ditandai oleh hiperglikemia kronis.
Afdal ., Eka Agustia Rini
doaj  

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Problems of applying inflammatory markers to diagnostics of anemia of chronic disease in patients with type 1 and type 2 diabetes

Медицинская иммунология
The purpose of the study was to evaluate the severity of changes in the values of markers-candidates for the differential diagnosis of anemia of chronic diseases in patients with type 1 and type 2 diabetes mellitus.
N. N. Musina, T. S. Prokhorenko, T. V. Saprina, A. P. Zima   +3 more
doaj   +1 more source

Diabetes mellitus type 1

, 2018
Bakgrunn: Vi har valgt å gjøre en systematisk litteraturstudie om ungdom og diabetes type 1, da dette er svært utbredt hos barn og unge i dag og statistikken viser økende tilfeller. Vi synes også det er interessant å ta for oss ungdom da de er i en livsfase hvor det skjer store fysiske og psykiske endringer.
Drage, Caroline Aasebø, Hauge, Martine Almestad   +1 more
openaire   +1 more source

The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population [PDF]

, 2010
Dănuţ Cimponeriu, P. Apostol, I Radu, Anne Marie Crăciun, Cristian Serafinceanu, Mihai Toma, Cristian Panaite, D Cheţa   +7 more
openalex   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

PHARMACOLOGICAL NEUROPROTECTION OF TYPE 1 DIABETES MELLITUS

Ukrainian Scientific Medical Youth Journal, 2016
Type 1 diabetes mellitus (DM) - one of the most common diseases of modern endocrinology. The growing number of sick children, emergence of chronic diseases and high percentage of disability determine the severity of the problem. Diabetic neuropathy (DN),
O. Fitsner, M. Khaitovych
doaj  

A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds

Advanced Science, EarlyView.
The Polyphenol+PDGF‐BB scaffold fabrication (Panel A) and its dual wound healing effects (Panel B: anti‐inflammation and accelerated tissue remodeling). ABSTRACT Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments ...
Lei Yi, Wanqian Li, Ying Duanmu, Zihan Zhang, Shixuan Chen, Shichu Xiao, Lei Du, Miaomiao Wei   +7 more
wiley   +1 more source