Results 91 to 100 of about 1,142,469 (262)

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population‐Based Study and Gut Microbiota Analysis

Advanced Science, EarlyView.
Frequent sweetened beverage consumption is associated with accelerated biological aging in a large Chinese population. Five gut microbial genera are consistently enriched in both frequent sweetened beverage consumers and individuals with accelerated aging and show significant mediating effects, suggesting a potential microbiota‐related pathway linking ...
Yuwei Shi, Xinmei Li, Yufan Hao, Qiaoyu Wu, Yuji Yu, Siyu Li, Nuo Xu, Yi‐Hsuan Wu, Eunhye Lee, Chi Chang, Emily Hu, Ying Lu, Elizabeth Delzell, Ann W. Hsing, Shankuan Zhu   +14 more
wiley   +1 more source

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Microparticles in type 2 diabetes mellitus [PDF]

Journal of Thrombosis and Haemostasis, 2005
DAVI', Giovanni, FERRONI P.
openaire   +3 more sources

A Dual‐Modal Wearable PPG Smartwatch with AI‐Enhanced Correction for High‐Accuracy and Continuous AF Burden Assessment

Advanced Science, EarlyView.
ABSTRACT Atrial fibrillation (AF) increases the risk of stroke and heart failure, yet accurate quantification of AF burden in daily life remains difficult. Although smartwatch photoplethysmography (PPG) supports continuous monitoring, complex rhythms and signal noise can impair burden estimation.
Song Zuo, Jinglei Wang, Xin Wang, Han Feng, Yize Zhao, Fadong Li, Shaobin Wei, Le Zhou, Zixu Zhao, Songjie Chen, Xiangyi Kong, Jue Wang, Liu He, Shijun Xia, Xin Li, Junmeng Zhang, Xiaoxia Liu, Xueyuan Guo, Ning Zhou, Songnan Li, Chenxi Jiang, Ribo Tang, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Wenwu Zhu, Changsheng Ma   +27 more
wiley   +1 more source

Pylorus‐Preserving Gastrectomy for Gastric Cancer: Current Evidence and Future Directions

Annals of Gastroenterological Surgery, EarlyView.
This review aims to outline the current evidence and future directions of PPG, focusing on the feasibility of extending its application beyond its traditional indications. ABSTRACT Pylorus‐preserving gastrectomy (PPG) is a function‐preserving surgery for clinically T1N0M0 (cT1N0M0) early gastric cancer (EGC) located in the middle third of the stomach ...
Sa‐Hong Kim, Hyuk‐Joon Lee
wiley   +1 more source

Very Long‐Term Outcomes of Laparoscopic Adjustable Gastric Banding in a Japanese Cohort: A Single‐Center 15‐Year Follow‐Up Study

Annals of Gastroenterological Surgery, EarlyView.
Long‐term outcomes of laparoscopic adjustable gastric banding (LAGB) in Japan were retrospectively evaluated in 28 patients with up to 15 years of follow‐up. LAGB achieved sustained long‐term weight reduction in selected patients; however, recurrence of metabolic comorbidities increased during extended follow‐up.
Yuichi Endo, Hiroomi Takayama, Wataru Miyoshino, Shun Nakamura, Yuiko Nagasawa, Masahiro Kawamura, Yoko Kawano, Takashi Masuda, Teijiro Hirashita, Yoshinori Ozeki, Takayuki Masaki, Hirotaka Shibata, Masafumi Inomata   +12 more
wiley   +1 more source

Diabetic Retinopathy Classification With Convolutional Neural Networks Designed by the Fuzzy Grey Wolf Optimizer With Parameter Adaptation

AI &Innovation, EarlyView.
ABSTRACT The detection and classification of diseases have become a field of interest for artificial intelligence in recent years, where the development of methods and models that allow support for specialists in different health fields has allowed early detection of diseases and the provision of timely treatment to patients.
Rodrigo Cordero‐Martínez, Daniela Sánchez, Patricia Melin   +2 more
wiley   +1 more source

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source

The Risk of Cardiovascular Diseases for Shift Workers in the Prospective Heinz Nixdorf Recall Study

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Shift work can disrupt circadian rhythms and is postulated to play a role in cardiovascular diseases (CVD). In the German prospective population‐based Heinz Nixdorf Recall Study, we analyzed longitudinal associations between shift work and night‐shift work with CVD.
Katharina Wichert, Sylvia Rabstein, Raimund Erbel, Lewin Eisele, Marina Arendt, Nico Dragano, Karl‐Heinz Jöckel, Thomas Behrens   +7 more
wiley   +1 more source