Results 111 to 120 of about 29,969,747 (258)

Association between BMI measured within a year after diagnosis of type 2 diabetes and mortality [PDF]

, 2013
OBJECTIVE: To describe the association of BMI with mortality in patients diagnosed with type 2 diabetes. RESEARCH DESIGN AND METHODS: Using records of 106,640 patients in Scotland, we investigated the association between BMI recorded around the diagnosis
McKnight, J., Walker, Jeremy J., Morris, A., Sattar, N, Sattar, N., Wild, S., McKnight, J, Philip, Sam, Morris, Andrew, Wild, Sarah, Lindsay, R., Leese, Graham, Walker, JJ, Leese, G, McKnight, John, Group, Scottish Diabetes Research Network Epidemiology, Morris, A, Walker, J.J., Lindsay, Robert, Leese, G., Sattar, Naveed, Logue, J., Philip, S, Logue, J, Wild, Sarah; id_orcid, ?, ?, Logue, Jennifer, Walker, Jeremy J, Philip, S., Lindsay, R, Wild, S   +30 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Preventive pharmacotherapy in type 2 diabetes mellitus

Indian Journal of Endocrinology and Metabolism, 2012
Over the last few decades certain demographic changes have been observed worldwide, which have led to an increase in the prevalence of chronic non-communicable diseases.
Neeraj Choudhary, Sanjay Kalra, Ambika Gopalakrishnan Unnikrishnan, T P Ajish   +3 more
doaj   +1 more source

Type 2 diabetes mellitus and osteoarthritis

Seminars in Arthritis and Rheumatism, 2019
Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are common diseases that frequently co-exist, along with overweight/obesity. While the mechanical impact of excess body weight on joints may explain lower limb OA, we sought to explore whether T2DM is linked to OA outside of excess weight and whether T2DM may play a role in OA pathophysiology. The
Veronese, Nicola, Cooper, Cyrus, Reginster, Jean-Yves, Hochberg, Marc, Branco, Jaime, Bruyère, Olivier, Chapurlat, Roland, Al-Daghri, Nasser, Dennison, Elaine, Herrero-Beaumont, Gabriel, Kaux, Jean-François, Maheu, Emmanuel, Rizzoli, Rene, Roth, Roland, Rovati, Lucio C., Uebelhart, Daniel, Vlaskovska, Mila, Scheen, André   +17 more
openaire   +8 more sources

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Polymorphisms of the _ENPP1_ gene are not associated with type 2 diabetes or obesity in the Chinese Han population [PDF]

, 2008
*Objective:* Type 2 Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia and with a major feature of insulin resistance. Genetic association studies have suggested that _ENPP1_ might play a potential role in susceptibility to ...
Daizhan Zhou, Sheng Li, Yun Liu, He Xu, Lin He, Zuofeng Zhang, Zhuo Chen, Simin Liu, Lan Yu, Teng Zhao, Guoyin Feng, Di Zhang   +11 more
core  

A model to estimate the lifetime health outcomes of patients with Type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68) [PDF]

, 2004
<i>Aims/hypothesis</i> The aim of this study was to develop a simulation model for Type 2 diabetes that can be used to estimate the likely occurrence of major diabetes-related complications over a lifetime, in order to calculate health ...
Stevenson, R.J., Gray, Alastair, Stevens, Richard, Briggs, AH, Holman, RR, Farmer, A.J., Holman, Rury, Fenn, P., Stevens, RJ, Clarke, P.M., Fenn, P,, Fenn, P, Stevens, R.J., Stratton, I.M., Farmer, Andrew, Gray, A, Gray, AM, Farmer, AJ, Stratton, IM, Holman, R, Matthews, D.R., Matthews, DR, Briggs, A., Clarke, PM, Briggs, A, the UK Prospective Diabetes Study (UKPDS) Group, Gray, A.M., Holman, R.R.   +27 more
core   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Trends in the prevalence and management of diagnosed type 2 diabetes 1994-2001 in England and Wales. [PDF]

, 2005
BACKGROUND: Type 2 diabetes is an important cause of morbidity and mortality. Its prevalence appears to be increasing. Guidelines exist regarding its management. Recommendations regarding drug therapy have changed.
Sismanidis, Charalambos, Nicky Richards, Lusignan, S, Lusignan, Simon, Derek G Cook, DeWilde, Stephen, DeWilde Stephen, Iain M Carey, Stephen DeWilde, Carey Iain M, Simon de Lusignan, Cook, Derek G, Charalambos Sismanidis, Cook Derek G, Richards, N, de Lusignan Simon, DeWilde, S, Sismanidis, C, Carey, IM, Richards, Nicky, Sismanidis Charalambos, Richards Nicky, Cook, DG, Carey, Iain M   +23 more
core   +2 more sources

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source