Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development
Advanced Science, EarlyView.This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen +11 more
wiley +1 more source
Efficacy, safety and dose–response relationship of teneligliptin, a dipeptidyl peptidase‐4 inhibitor, in Japanese patients with type 2 diabetes mellitus [PDF]
, 2013 Takashi Kadowaki, Kazuoki Kondo
openalex +1 more source
Single‐Cell Metabolic Imaging Reveals Glycogen‐Driven Adaptations in Endothelial Cells
Advanced Science, EarlyView.Single‐cell metabolic imaging of diabetes‐associated endothelial dysfunction by SRS microscopy reveals dynamic glycogen storage and its role in modulating metabolic adaptations under glucose starvation. Abstract Endothelial dysfunction (ED) is a defining feature of diabetes mellitus (DM) and a key contributor to many metabolic and cardiovascular ...
Rahuljeet S. Chadha +13 more
wiley +1 more source
Type 2 Diabetes Mellitus Is Associated With Faster Degeneration of Bioprosthetic Valve [PDF]
, 2011 Roberto Lorusso +31 more
openalex +1 more source
Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6
Advanced Science, EarlyView.Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu +9 more
wiley +1 more source
Glycemic Variability and Type 2 Diabetes Mellitus [PDF]
Applied Medical Informatics, 2013 Aim: The purpose of the present study was to quantify glucose variability in type 2 diabetic patients and establishing relationship with cardiometabolic parameters and type of glucose-lowering treatment.
Nicolae HÂNCU +2 more
doaj
HUBUNGAN LAMA MENDERITA DIABETES MELLITUS TIPE 2 TERHADAP PENURUNAN FUNGSI KOGNITIF PADA PASIEN LANJUT USIA [PDF]
, 2016 ABSTRAKGangguan kognitif sering dijumpai pada penderita Diabetes Mellitus (DM) sebagai akibat dari komplikasi mikrovaskular maupun makrovaskuler. Sampai saat ini studi yang meneliti hubungan lama menderita DM dengan gangguan fungsi kognitif masih ...
Syarifah Sulfira Mulia
core
Type 2 diabetes in Tirana City, Albania: a rapid increase in a country in transition.
, 2004 AIMS: To determine how the prevalence of Type 2 diabetes mellitus has changed in Tirana, the capital of Albania, over 20 years. METHODS: Cluster sampling was used to select 700 households including 1540 adults 25 years of age and over in Tirana City ...
Coker, R, McKee, M, Shapo, L, Ylli, A
core +1 more source
Advanced Science, EarlyView.This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao +5 more
wiley +1 more source
Mean Platelet Volume is Associated with Glycaemic Control and Retinopathy in Patients with Type 2 Diabetes Mellitus [PDF]
, 2013 Sevim Dindar +3 more
openalex +1 more source