Results 61 to 70 of about 1,643,238 (355)

Plasma tyrosine and its interaction with low high‐density lipoprotein cholesterol and the risk of type 2 diabetes mellitus in Chinese

Journal of Diabetes Investigation, 2019
Aims/Introduction Metabolomic markers have the potential to improve the predicting accuracy of existing risk scores for type 2 diabetes mellitus. The present study aimed to test the associations between plasma tyrosine and type 2 diabetes mellitus with ...
Jing Li, Yun‐Feng Cao, Xiao‐Yu Sun, Liang Han, Sai‐Nan Li, Wen‐Qing Gu, Min Song, Chang‐tao Jiang, Xilin Yang, Zhong‐ze Fang   +9 more
doaj   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Skeletal Fragility in Type 2 Diabetes Mellitus [PDF]

Endocrinology and Metabolism, 2018
Type 2 diabetes (T2D) is associated with an increased risk of fracture, which has been reported in several epidemiological studies. However, bone mineral density in T2D is increased and underestimates the fracture risk.
Jakob Starup-Linde, Katrine Hygum, Bente Lomholt Langdahl   +2 more
doaj   +1 more source

Type 2 Diabetes Mellitus: A Pathophysiologic Perspective

Frontiers in Nutrition, 2021
Type 2 Diabetes Mellitus (T2DM) is characterized by chronically elevated blood glucose (hyperglycemia) and elevated blood insulin (hyperinsulinemia). When the blood glucose concentration is 100 milligrams/deciliter the bloodstream of an average adult ...
Eric C. Westman
doaj   +1 more source

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Journal of Diabetes Research, 2020
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence.
D. Tănase, Evelina Maria Gosav, C. Costea, M. Ciocoiu, C. Lacatusu, M. Mărănducă, A. Ouatu, M. Floria   +7 more
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs

Molecules, 2020
Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of population and according to the World Health Organization (WHO) the number of adults living with diabetes is expected to increase.
Angelica Artasensi, A. Pedretti, G. Vistoli, L. Fumagalli   +3 more
semanticscholar   +1 more source

Quantity and Volume of Perivascular Spaces Are Inversely Associated With Multiple Sclerosis Relative to Cerebrovascular Disease and Migraine

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To quantify the number and volume of whole brain perivascular spaces (PVS) using a detection and segmentation algorithm in participants with multiple sclerosis (MS) and patients with disorders mimicking MS known to potentially influence PVS, such as cerebrovascular disease.
Elle M. Levit, Elizabeth A. Horwath, Daniel L. Schwartz, Lisa C. Silbert, Russell T. Shinohara, Andrew J. Solomon   +5 more
wiley   +1 more source

Epidemiology of Type 2 Diabetes – Global Burden of Disease and Forecasted Trends

Journal of Epidemiology and Global Health, 2019
The rising burden of type 2 diabetes is a major concern in healthcare worldwide. This research aimed to analyze the global epidemiology of type 2 diabetes.
Moien A. B. Khan, M. J. Hashim, J. King, R. Govender, H. Mustafa, Juma Al Kaabi   +5 more
semanticscholar   +1 more source

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Frontiers in Immunology, 2020
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM).
Gholamreza Daryabor, M. Atashzar, D. Kabelitz, S. Meri, K. Kalantar   +4 more
semanticscholar   +1 more source