Results 141 to 150 of about 5,358,430 (249)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Moving from Evidence to Implementation of Breakthrough Therapies for Diabetic Kidney Disease.

, 2022
Diabetic kidney disease is the most frequent cause of kidney failure, accounting for half of all cases worldwide. Moreover, deaths from diabetic kidney disease increased 106% between 1990 and 2013, with most attributed to cardiovascular disease ...
Tuttle, Katherine, St Peter, Wendy, Roberts, Glenda, Wong, Leslie, Harris, Raymond C, Rangaswami, Janani, Brosius, Frank C, Mottl, Amy, Fowler, Kevin, Kliger, Alan S, Quaggin, Susan E, Diabetic Kidney Disease Collaborative Task Force,, Argyropoulos, Christos, Cherney, David, Gee, Patrick O   +14 more
core  

Life on the list: an exploratory study of the life world of individuals waiting for a kidney transplant

, 2010
Kidney transplantation is the treatment of choice for many individuals with end stage renal disease (ESRD), as transplantation is reported to offer a greater quality of life than renal dialysis.
Long-Sutehall, Tracy, Frankland, Jane, Addington-Hall, Julia, Sque, Magi, Mason, Juan   +4 more
core   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

The Longitudinal Effect of Impaired Kidney Function on Bone Mineral Density and the Association of Body Composition on Biomarkers of Kidney Function Among Afro-Caribbean Men of West African Ancestry [PDF]

, 2013
Background: Chronic kidney disease (CKD) is a rising global health problem. African Americans bear a greater proportion of CKD burden compared to Caucasians.
Egwuogu, Heartley
core  

Risk factors for cardiac valve calcification in patients with diabetic kidney disease

Linchuang shenzangbing zazhi, 2016
Objective To explore risk factors for cardiac valve calcification(CVC) in patients with diabetic kidney disease by detecting diabetic kidney disease heart valve calcification and analyzing the related factors.Methods 118 patients undergoing maintenance ...
ZHOU Li-na, CHEN Xin, ZHU Ying-ling, DONG Hong-hua, SHI Ying-qiu, XU Xiao-ling   +5 more
doaj  

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Diabetic Kidney Disease: Disease Progression Driven by Positive Feedback Loops and Therapeutic Strategies Targeting Pathogenic Pathways [PDF]

Gaozhi P Mo,1,* Yao Zhu,1,* Yue You,1 Hui Chen,1 Jiahao Zhang,1 Bunhav Ku,1 Haichuan Yu,1 Zhiyong Peng1,2 1Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China; 2Hubei Clinical ...
You Y, Zhu Y, Zhang J, Mo GP, Chen H, Yu H, Peng Z, Ku B   +7 more
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