Results 71 to 80 of about 28,020 (301)

Metformin protects from oxaliplatin induced peripheral neuropathy in rats

Neurobiology of Pain, 2020
Oxaliplatin is a commonly used drug to treat cancer, extending the rate of disease-free survival by 20% in colorectal cancer. However, oxaliplatin induces a disabling form of neuropathy resulting in more than 60% of patients having to reduce or ...
N.W. Martinez, A. Sánchez, P. Diaz, R. Broekhuizen, J. Godoy, S. Mondaca, A. Catenaccio, P. Macanas, B. Nervi, M. Calvo, F.A. Court   +10 more
doaj   +1 more source

Effect of an educational booklet for prevention and treatment of foot musculoskeletal dysfunctions in people with diabetic neuropathy: the FOotCAre (FOCA) trial II, a study protocol of a randomized controlled trial [PDF]

, 2020
E. Q. Silva, Eneida Yuri Suda, D.P. Santos, Jady L. Veríssimo, Jane S. S. P. Ferreira, Ronaldo H. Cruvinel Júnior, Renan Lima Monteiro, Cristina Dallemole Sartor, Isabel de Camargo Neves Sacco   +8 more
openalex   +1 more source

Safety and pharmacokinetics of a novel potent GABA analogue crisugabalin in Chinese subjects with various degrees of renal impairment

British Journal of Clinical Pharmacology, EarlyView.
Aims Crisugabalin is a novel calcium channel α2δ subunit ligand and a highly selective oral gamma‐aminobutyric acid (GABA) analogue developed for the treatment of diabetic peripheral neuropathic pain (DPNP) and postherpetic neuralgia (PHN). This study investigated pharmacokinetic properties and safety of crisugabalin in subjects with renal impairment ...
Shibeilei Lin, Ye Wang, Chao Hu, Yanhuan Feng, Xi Tang, Ping Fu, Jia Miao   +6 more
wiley   +1 more source

Machine learning methods for predicting adverse drug events: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo, Fatemeh Ahmadi, Mohammad Ali Omrani, Sheikh S. Abdullah, Neda Rostamzadeh, Atefeh Jafari, Lujain Izzedin, Kamran Sedig, Flory T. Muanda   +8 more
wiley   +1 more source

Cutting edge strategies for diabetic wound care: Nanotechnology, bioengineering, and beyond

BMEMat, EarlyView.
Graphical abstract illustrates the challenges in diabetic wound healing, covering pathophysiology, formulation hurdles, and emerging therapeutic strategies. It highlights the role of hyperglycemia, formulation complexities, and advanced technologies like bioprinting and AI in improving diabetic wound management. Abstract Diabetic wounds affect millions
Usama Ahmad, Wan Nurhidayah Wan Hanaffi, Anas Islam, Aimen Salman, Mohd Muazzam Khan, Faiyaz Shakeel, Qiang Cai, Xiaojun Cai, Quazi T. H. Shubhra   +8 more
wiley   +1 more source

Investigation of the role of miR-221 in diabetic peripheral neuropathy and related molecular mechanisms [PDF]

, 2021
Xiaole Wu, Xiaoyu Wang, Yiyu Yin, Lei Zhu, Fengchao Zhang, Jianping Yang   +5 more
openalex   +1 more source

Copper‐doped borosilicate bioactive glass coating modified bacterial cellulose functional dressing for diabetic ulcer

BMEMat, EarlyView.
For the first time, a borosilicate‐based bioactive glass coating was successfully formed on the surface of bacterial cellulose nanofibers. A copper‐doped borosilicate bioactive glass coating‐modified bacterial cellulose functional dressing was designed for the management of chronic wounds, such as diabetic ulcers.
Haiyong Ao, Dingyun Wang, Le Ma, Maohu Wang, Dongxue Zhang, Xiaowei Xun, Xidong Wu, Meili Zhang, Jiajia Zong   +8 more
wiley   +1 more source

Diabetic amyotrophy: Atypical presentation compared with common diabetic neuropathies. [PDF]

Can Fam Physician, 2023
Sharma A, Jattan A.
europepmc   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

DES‐Promoted Synthesis of 3,4‐Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies

Chemistry &Biodiversity, EarlyView.
DES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Gobind Kumar, Sahil Mishra, Pule Seboletswe, Nontobeko Gcabashe, Lalitha Gummidi, Neha Manhas, Talent Makhanya, Gaurav Bhargava, Almahi Idris, Md. Shahidul Islam, Parvesh Singh   +10 more
wiley   +1 more source