Results 81 to 90 of about 23,070 (296)

Adaptação transcultural para o português brasileiro do Michigan Neuropathy Screening Instrument : MNSI-Brasil [PDF]

, 2016
Desde 1994, o Centro de Treinamento e Pesquisa em Diabetes da Universidade de Michigan propôs um instrumento não ainda adaptado para uso no Brasil para mensurar neuropatias.
Azevedo, Diego Igor de Oliveira, Bezerra, Arthur Rodrigues, Botelho, Kárenn Klycia Pereira, Martins, Emerson Fachin, Oliveira, Franassis Barbosa de, Santos-Couto-Paz, Clarissa Cardoso dos   +5 more
core   +1 more source

Coacervates Made of Elastin‐Like Polypeptides Fused with Melanocyte‐Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord‐Injured Mice

Advanced Healthcare Materials, EarlyView.
Pressure skin wounds are frequent complications after spinal cord injury (SCI), with impaired healing due to vascular and immune deficits. Elastin‐like polypeptides (ELP) fused to α‐MSH (MSH‐ELP) or MCP‐1 (MCP‐ELP) are developed and tested on these wounds. The resulting nanoparticles are non‐toxic and bioactive, and they enhance macrophage recruitment,
Suneel Kumar, Dhruv Patel, Greeshma Manjunath, Shashank Madhavan, Ashley Mathew, Dnyaneshwari Rananavare, Jahnavi Shah, Francois Berthiaume   +7 more
wiley   +1 more source

Diabetic cardiovascular autonomic neuropathy: risk factors, clinical impact and early diagnosis [PDF]

, 2008
Cardiovascular autonomic neuropathy (CAN) is one of the most clinically significant complications of diabetes mellitus (DM), but one of the least frequently diagnosed.
Chacra, Antonio Roberto, Dib, Sergio Atala, Rolim, Luiz Clemente de Souza Pereira, Sá, João Roberto de   +3 more
core   +3 more sources

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Corneal nerve fractal dimension: a novel corneal nerve metric for the diagnosis of diabetic sensorimotor polyneuropathy [PDF]

, 2018
Objective: Corneal confocal microscopy (CCM), an in vivo ophthalmic imaging modality, is a noninvasive and objective imaging biomarker for identifying small nerve fiber damage.
Alam, Uazman, Asghar, Omar, Azmi, Shazli, Chen, Xin, Efron, Nathan, Ferdousi, Maryam, Graham, Jim, Malik, Rayaz A., Marshall, Andrew, Petropoulos, Ioannis N., Ponirakis, Georgios   +10 more
core   +2 more sources

Diabetic Somatic Neuropathies [PDF]

Diabetes Care, 2004
ropathic pain (7–10), and this and other putative mechanisms will be discussed. The clinical features, diagnosis, and management of the focal and multifocal neuropathies will be described. A major portion of this review will discuss the clinical features, assessment, and management of the patient with the most common form of DN, diabetic distal sensory
Boulton, Andrew J M, Malik, Rayaz A., Arezzo, Joseph C., Sosenko, Jay M.   +3 more
openaire   +2 more sources

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, EarlyView.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

Toxic and drug-induced peripheral neuropathies: updates on causes, mechanisms and management. [PDF]

, 2013
PURPOSE OF REVIEW: This review discusses publications highlighting current research on toxic, chemotherapy-induced peripheral neuropathies (CIPNs), and drug-induced peripheral neuropathies (DIPNs).
Buclin, T., Diezi, M., Kuntzer, T.
core   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Gait parameters in patients with diabetes mellitus

Revista Brasileira de Cineantropometria e Desempenho Humano, 2010
Diabetes mellitus is a chronic disease that results in sensorimotor alterations. These changes affect balance and walking and predispose affected patients to falls.
Cristina Elena Prado Teles Fregonesi, Marcela Regina Camargo   +1 more
doaj