Results 101 to 110 of about 23,070 (296)

Metformin protects from oxaliplatin induced peripheral neuropathy in rats

Neurobiology of Pain, 2020
Oxaliplatin is a commonly used drug to treat cancer, extending the rate of disease-free survival by 20% in colorectal cancer. However, oxaliplatin induces a disabling form of neuropathy resulting in more than 60% of patients having to reduce or ...
N.W. Martinez, A. Sánchez, P. Diaz, R. Broekhuizen, J. Godoy, S. Mondaca, A. Catenaccio, P. Macanas, B. Nervi, M. Calvo, F.A. Court   +10 more
doaj   +1 more source

Diabetic Neuropathy Collection: Treatment of Diabetic Neuropathy [PDF]

Diabetes Therapy, 2020
Video: Treatment of Diabetic Neuropathy podcast recording (MP4 61908 kb).
openaire   +2 more sources

Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects

Animal Models and Experimental Medicine, EarlyView.
Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu, Jiaqi Chen, Zhonghui Li, Jiamin Zhou, Hui Zhang, Yujia Yu, Feng Cheng, Jie Bao, Chunhan Feng, Xiangqu Yu, Zhao Xia, Rao Ding, Xiang Li   +12 more
wiley   +1 more source

A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration [PDF]

, 2012
Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of ...
Bhattacharya, Martha R.C., DiAntonio, Aaron, Ebstein, Sarah Y, Gerdts, Josiah, Milbrandt, Jeffrey, Naylor, Sarah A, Royse, Emily X, Sasaki, Yo   +7 more
core   +2 more sources

Diabetic Neuropathy Collection: Introduction to Diabetic Neuropathy [PDF]

Diabetes Therapy, 2020
Introduction to Diabetic Neuropathy podcast recording (MP4 55526 kb).
openaire   +2 more sources

Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies

Animal Models and Experimental Medicine, EarlyView.
This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang, Baoying Xu, Xinru Chen, Yu Chen, Dehong Yu   +4 more
wiley   +1 more source

Visual Hypersensitivity as a Transdiagnostic Marker of Surgical Pain Response in Arthritis and Chronic Pain Syndromes

Arthritis &Rheumatology, EarlyView.
Objective Nociplastic pain is pain primarily driven by the central nervous system and, unlike nociceptive pain conditions, is thought to be refractory to peripherally directed therapies. Nociplastic pain is also associated with hypersensitivity to painful and other sensory stimuli (such as visual stimuli). Nonpainful sensory measures have not been well
Noah Waller, Steven E. Harte, Richard E. Harris, Andrew Schrepf, Tristin Smith, Eric Ichesco, Chelsea Kaplan, Flavia Sunzini, Deeba Minhas, Wendy Marder, Sara R. Till, David A. Williams, Chad M. Brummett, Neil Basu, Sawsan As‐Sanie, Daniel J. Clauw   +15 more
wiley   +1 more source

Is resistance to ischaemia of motor axons in diabetic subjects due to membrane depolarization? [PDF]

, 1990
The reasons for the resistance to ischaemia of peripheral nerves in diabetics are not well understood. We have now explored whether axonal depolarization underlies this phenomenon, as has previously been proposed.
Baker, Barrett, Bergmans, Bergmans, Bostock, Das, Dyck, Gilliat, Greene, Gregersen, Horowitz, Hugh Bostock, Jaramillo, Klaus Piwernetz, Low, Low, Ludin, Masson, Michael Strupp, Newrick, Oh, Parry, Paul Weigl, Peter Grafe, Ritchie, Rolf Renner, Shirabe, Steiness, Steiness, Steiness, Strupp, Stöhr, Thomas, Tuck, Weigl   +34 more
core   +1 more source

Suprainguinal Lateral Femoral Cutaneous Neurectomy for Recurrent Meralgia Paresthetica: A Technique Guide

Arthroscopy Techniques, EarlyView.
Abstract Meralgia paresthetica (MP) is a neuropathy caused by injury or compression of the lateral femoral cutaneous nerve (LFCN), presenting as numbness, tingling, or burning pain in the lateral thigh. While surgical decompression has traditionally been a common surgical treatment for MP, recently, fully transecting the LFCN is increasingly becoming ...
Joshua T. Finerty, Allison R. Garden, Manuel A. Romero‐Padron, Joshua S. Everhart   +3 more
wiley   +1 more source

Cost–benefit analysis of screening programme for diabetic retinopathy in Bulgaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Late‐diagnosed diabetic retinopathy (DR) is difficult and expensive to treat. Screening programmes can identify the disease early and reduce the costs of its future treatment. This study aims to analyse the cost–benefit of screening programmes for DR.
Iva Nenkova, Yoana Lilova, Alexander Oscar, Alina Levi, Maria Kamusheva, Guenka Petrova   +5 more
wiley   +1 more source