Results 161 to 170 of about 150,695 (362)

Thymosin β4 promotes the recovery of peripheral neuropathy in type II diabetic mice

Neurobiology of Disease, 2012
Peripheral neuropathy is one of the most common complications of diabetes mellitus. Using a mouse model of diabetic peripheral neuropathy, we tested the hypothesis that thymosin β4 (Tβ4) ameliorates diabetes‐induced neurovascular dysfunction in the ...
Lei Wang, Michael Chopp, Alexandra Szalad, Zhongwu Liu, Mei Lu, Li Zhang, Jing Zhang, Rui Lan Zhang, Dan Morris, Zheng Gang Zhang   +9 more
doaj  

Epidermal Collagen Reduction Drives Selective Aspects of Aging in Sensory Neurons

Aging Cell, Volume 24, Issue 4, April 2025.
Reduced collagen on the epidermal apical surface drives selective aging in sensory neurons of Caenorhabditis elegans, leading to excessive dendritic branching and related functional deficits. An immunoglobulin superfamily protein in interneurons acts upstream of collagen genes to maintain dendritic homeostasis during aging, with a downstream ...
Meera M. Krishna, Swapnil G. Waghmare, Ariel L. Franitza, Emily C. Maccoux, Lezi E   +4 more
wiley   +1 more source

Serum Vitamin D Levels in Patients with Type 2 Diabetes Mellitus with and without Peripheral Neuropathy

JK Science
Introduction: Serum vitamin D levels has been hypothesized to influence the progress of diabetes and its various complications. The role of Vitamin D in diabetic peripheral neuropathy have been debated.
Tammineni Roja, Siba Prasad Dalai, Gyanendra Sathua Mahapatra, Samir Sahu, Jonnalagadda Vihari, Lohitha Bhavani Jasthi   +5 more
doaj  

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, EarlyView.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

Clinical Efficacy of Fidarestat, a Novel Aldose Reductase Inhibitor, for Diabetic Peripheral Neuropathy [PDF]

, 2001
Nigishi Hotta, Takayoshi Toyota, Kempei Matsuoka, Yukio Shigeta, Ryuichi Kikkawa, Toshio Kaneko, Akira Takahashi, K. Sugimura, Yasuo Koike, Jun Ishii, Nobuo Sakamoto   +10 more
openalex   +1 more source

Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange

Aging Cell, EarlyView.
Therapeutic plasma exchange safely reduces biological age by up to 2.6 years. Multi‐omics analysis reveals coordinated cellular and molecular responses associated with aging rejuvenation. ABSTRACT We conducted a randomized, placebo‐controlled trial to assess the safety and biological age (BA) effects of various therapeutic plasma exchange (TPE ...
Matias Fuentealba, Dobri Kiprov, Kevin Schneider, Wei‐Chieh Mu, Prasanna Ashok Kumaar, Herbert Kasler, Jordan B. Burton, Mark Watson, Heather Halaweh, Christina D. King, Zehra Stara Yüksel, Chelo Roska‐Pamaong, Birgit Schilling, Eric Verdin, David Furman   +14 more
wiley   +1 more source

4-g Monofilament Is Clinically Useful for Detecting Diabetic Peripheral Neuropathy [PDF]

, 2001
Yukihiro Nagai, Yu Sugiyama, Toshio Abe, G Nomura   +3 more
openalex   +1 more source

Incorporating familial risk, lifestyle factors, and pharmacogenomic insights into personalized noncommunicable disease (NCD) reports for healthcare funder beneficiaries participating in the Open Genome Project

Annals of Human Genetics, EarlyView.
Abstract Introduction An ethics‐guided decision‐making framework was developed for applying pathology‐supported genetic testing, a multifaceted pharmacodiagnostic approach that translates population risk stratification into clinical utility. We introduce this service, supported by the Open Genome Project, which aligns with the beneficence principle in ...
Manie De Klerk, Nicole Van Der Merwe, Johny Erasmus, Lindiwe Whati, Kelebogile E. Moremi, Daniel W. Olivier, Maritha J. Kotze   +6 more
wiley   +1 more source

Clinical study of Jinmaitong composita ("Equation missing")on diabetic peripheral neuropathy)on diabetic peripheral neuropathy [PDF]

, 2001
Xiao‐chun Liang, Liying Cui, Sai-shan Guo, Kejian Zhang, Weixin Hao, Jia Li, Hong Zhang, Renyu Sun, Ben-hong Li, Hong Du   +9 more
openalex   +1 more source

Survivorship Needs and Experiences of Survivors of Head and Neck Cancer in Rural Australia: A Qualitative Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Semi‐structured interviews with 17 rural head and neck cancer survivors revealed six main themes relating to their survivorship needs and experiences: 1) financial impacts, 2) physical effects, 3) psychosocial effects, 4) clinical management, 5) information and support needs, and 6) access.
Poorva Pradhan, Helen Hughes, Ashleigh R. Sharman, Judith Lacey, Patrick Dwyer, Jacques Hill, Kimberley J. Davis, Steven Craig, Raymond Wu, Bruce Ashford, Jenny Mitchell, Jonathan R. Clark, Michael Elliott, Carsten E. Palme, Rebecca L. Venchiarutti   +14 more
wiley   +1 more source