Results 51 to 60 of about 1,023,691 (284)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Journal of Diabetes Research, 2017
Objective. To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Methods. We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic ...
Fengyi Wang, Jiaqi Zhang, Jiadan Yu, Shaxin Liu, Rengang Zhang, Xichao Ma, Yonghong Yang, Pu Wang   +7 more
doaj   +1 more source

status and insulin resistance in diabetic peripheral neuropathy

Journal of Bangladesh Society of Physiologists, 2016
Background: Complication of diabetes mellitus includes peripheral neuropathy which causes ischemic foot ulceration. Hyperglycemia and insulin resistance may accelerate the development of diabetic peripheral neuropathy.
Taslima Akter, Qazi Shamima Akhter, Mezbahur Rahman, Sabrina Fahmida Azim   +3 more
doaj   +1 more source

Perspectives of glycemic variability in diabetic neuropathy: a comprehensive review

Communications Biology, 2021
Zhang et al. describe metrics for evaluating glycaemic variability (GV) in clinical practice and summarize the role and related mechanisms of GV in diabetic neuropathy, including cardiovascular autonomic neuropathy, diabetic peripheral neuropathy and ...
Xiaochun Zhang, Xue Yang, Bao Sun, Chunsheng Zhu   +3 more
doaj   +1 more source

The Influence of Diabetic Peripheral Neuropathy on the Duration of Sciatic Nerve Block with 1.3% Liposomal Bupivacaine and 0.25% Bupivacaine Hydrochloride in a Mouse Model

Pharmaceutics, 2022
Little is known regarding the pharmacological properties of extended-release local anesthetics in the setting of diabetic peripheral neuropathy. We investigated and compared the duration of sciatic nerve block following administration of clinically ...
Liljana Markova, Erika Cvetko, Chiedozie Kenneth Ugwoke, Simon Horvat, Nejc Umek, Tatjana Stopar Pintarič   +5 more
doaj   +1 more source

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

Advanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang, Shaowen Zhuo, Binyu Song, Jinan Chen, Xin Zhao, Sijia Li, Shuang You, Dong Jiang, Yuedong Chen, Juanli Dang, Tong Wang, Baolin Guo, Zhou Yu, Baoqiang Song   +13 more
wiley   +1 more source

Tadalafil Promotes the Recovery of Peripheral Neuropathy in Type II Diabetic Mice. [PDF]

PLoS ONE, 2016
We previously demonstrated that treatment of diabetic peripheral neuropathy with the short (4 hours) half-life phosphodiesterase 5 (PDE5) inhibitor, sildenafil, improved functional outcome in diabetic db/db mice.
Lei Wang, Michael Chopp, Alexandra Szalad, XueRong Lu, LongFei Jia, Mei Lu, Rui Lan Zhang, Zheng Gang Zhang   +7 more
doaj   +1 more source

Early diagnosis of neuropathy in leprosy: comparing diagnostic tests in a large prospective study (the INFIR Cohort Study) [PDF]

, 2008
BackgroundLeprosy is the most frequent treatable neuromuscular disease. Yet, every year, thousands of patients develop permanent peripheral nerve damage as a result of leprosy.
Wilder-Smith, Einar P, Pramila Barkataki, van Brakel, Wim H, van Brakel Wim H., Wim H van Brakel, Diana N J Lockwood, Einar P Wilder-Smith, Nicholls Peter G., Peter G Nicholls, Wilder-Smith Einar P., Nicholls, Peter G, Lockwood Diana N. J., Das Loretta, INFIR Study Group, Nicholls, Peter G., Lockwood, Diana N.J, Das, Loretta, Barkataki, Pramila, Barkataki Pramila, van Brakel, W.H., Loretta Das, Wilder-Smith, Einar P., Lockwood, Diana NJ   +22 more
core   +2 more sources

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Diabetes: how to manage diabetic peripheral neuropathy

Drugs in Context, 2022
Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus. Tight glycaemic management focused on lowering haemoglobin A1C and increasing time in the target glucose range along with metabolic risk factor management form the cornerstone of DPN prevention.
Megha Gandhi, Emily Fargo, Lalita Prasad-Reddy, Katherine M Mahoney, Diana Isaacs   +4 more
openaire   +3 more sources