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Properties and functions of diacylglycerol kinases
Cellular Signalling, 2000Diacylglycerol kinases (DGKs) phosphorylate the second-messenger diacylglycerol (DAG) to phosphatidic acid (PA). The family of DGKs is well conserved among most species. Nine mammalian isotypes have been identified, and are classified into five subgroups based on their primary structure.
Brahim Houssa, Wim J. van Blitterswijk
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2009
Diacylglycerol kinase (DGK, EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). DGK belongs to a well-conserved family of proteins found in diverse species, such as Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, mammals, plants, and bacteria (Merida et al.
Arisz, S.A., Munnik, T.
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Diacylglycerol kinase (DGK, EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). DGK belongs to a well-conserved family of proteins found in diverse species, such as Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, mammals, plants, and bacteria (Merida et al.
Arisz, S.A., Munnik, T.
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2003
Publisher Summary Diacylglycerol (DAG) is a prolific second messenger that activates proteins involved in a variety of signaling cascades. Because it can associate with a diverse set of proteins, DAG potentially activates numerous signaling cascades. Thus, its accumulation needs to be strictly regulated.
Steve M. Prescott, Matthew K. Topham
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Publisher Summary Diacylglycerol (DAG) is a prolific second messenger that activates proteins involved in a variety of signaling cascades. Because it can associate with a diverse set of proteins, DAG potentially activates numerous signaling cascades. Thus, its accumulation needs to be strictly regulated.
Steve M. Prescott, Matthew K. Topham
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Diacylglycerol kinases in signal transduction
Chemistry and Physics of Lipids, 1999Diacylglycerol kinase (DGK) phosphorylates the second messenger diacylglycerol (DAG) to phosphatidic acid. A family of nine mammalian isotypes have been identified. Their primary structure shows a diverse array of conserved domains, such as a catalytic domain, zinc fingers, pleckstrin homology domains and EF-hand structures, known to interact with ...
Wim J. van Blitterswijk, Brahim Houssa
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Angewandte Chemie, 2014
Solid-state NMR is a powerful tool for studying membrane proteins in a native-like lipid environment. 3D magic angle spinning (MAS) NMR was employed to characterize the structure of E.coli diacylglycerol kinase (DAGK) reconstituted into its native E.coli
Yanke Chen +5 more
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Solid-state NMR is a powerful tool for studying membrane proteins in a native-like lipid environment. 3D magic angle spinning (MAS) NMR was employed to characterize the structure of E.coli diacylglycerol kinase (DAGK) reconstituted into its native E.coli
Yanke Chen +5 more
semanticscholar +1 more source
Diacylglycerol, phosphatidic acid, and the converting enzyme, diacylglycerol kinase, in the nucleus
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006There exists phosphoinositide (PI) cycle in the nucleus, which is operated differentially from the classical PI cycle at the plasma membrane. Evidence has been accumulated that nuclear PIs and the related enzymes are closely involved in a variety of nuclear processes, although the details remain to be elucidated. In this mini review, some components of
Kaoru Goto +2 more
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[19] Arachidonoyl-specific diacylglycerol kinase
1992Publisher Summary This chapter describes an assay system and a chromatographic technique for separating the arachidonoyl-diacylglycerol kinase (DG kinase) from the nonspecific enzymes. The importance of the choice of detergent used in the assay for detecting the substrate preference of the arachidonoyl-DG kinase is also discussed.
John A. Glomset, Rozenn N. Lemaitre
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Diacylglycerol Kinases: Regulation and Signaling Roles
Thrombosis and Haemostasis, 2002SummaryDiacylglycerol kinases (DGKs) are thought to attenuate diacylglycerol signals by converting diacylglycerol to phosphatidic acid. The nine mammalian diacylglycerol kinases that have been identified are widely expressed, but each isoform has a unique tissue and subcellular distribution.
Stephen M. Prescott, Matthew K. Topham
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Nuclear diacylglycerol kinases: regulation and roles
Frontiers in Bioscience, 2008The diacylglycerol-kinases are a family of related lipid kinases. There are currently 10 known isoforms of diacylglycerol kinases that are categorized into five groups based on similarities in their primary sequence. All of these enzymes catalyze the transfer of the gamma-phosphate of ATP to one lipid second messenger, diacylglycerol, thereby ...
Daniel M. Raben, Becky Tu-Sekine
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Inhibition of diacylglycerol kinases as a physiological way to promote diacylglycerol signaling
Advances in Biological Regulation, 2014Diacylglycerol is a key regulator of cell physiology, controlling the membrane recruitment and activation of signaling molecules. Accordingly, diacylglycerol generation and metabolism are strictly controlled, allowing for localized regulation of its concentration.
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