Results 91 to 100 of about 5,439,941 (291)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Detection of malaria parasites in thick blood smear: A review

Communications in Science and Technology, 2018
Based on data from World Health Organization, in 2015, there are 90% of deaths caused by malaria disease in Africa, Southeast Asia and countries of eastern Mediterranean.
Faza Maula Azif, Hanung Adi Nugroho, Sunu Wibirama   +2 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Implementation of a Human-Computer Interface for Computer Assisted Translation and Handwritten Text Recognition [PDF]

, 2012
A human-computer interface is developed to provide services of computer assisted machine translation (CAT) and computer assisted transcription of handwritten text images (CATTI). The back-end machine translation (MT) and handwritten text recognition (HTR)
Ocampo Sepúlveda, Jorge Carlos
core  

Brain computer interface based robotic rehabilitation with online modification of task speed [PDF]

, 2013
We present a systematic approach that enables online modification/adaptation of robot assisted rehabilitation exercises by continuously monitoring intention levels of patients utilizing an electroencephalogram (EEG) based Brain-Computer Interface (BCI ...
Saraç, Mine, Mine Sarac, Çetin, Müjdat, Volkan Patoglu, Patoğlu, Volkan, Mujdat Cetin, Koyaş, Ela, Ela Koyas, Erdoğan, Ahmetcan, Ahmetcan Erdogan   +9 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Can computer assisted diagnosis (CAD) be used as a screening tool in the detection of pulmonary nodules when using 64-slice multidetector computed tomography?

International Journal of General Medicine, 2011
Zishan Haider1, Muhammad Idris1, Wasim A Memon1, Nazia Kashif1, Sidra Idris1, Zafar Sajjad1, Saeed Akram21Department of Radiology, Aga Khan University Hospital, Karachi, Pakistan; 2Medicine Department, Aga Khan University Hospital, Karachi ...
Haider Z, Idris M, Memon WA, Kashif N, Idris S, Sajjad Z, Akram S   +6 more
doaj  

21 st century workflow: A proposal

Journal of Pathology Informatics, 2014
Digital pathology is rapidly developing, but early systems have been slow to gain traction outside of niche applications such as: Second-opinion telepathology, immunostain interpretation, and intraoperative telepathology.
Jeffrey L Fine
doaj   +1 more source