Results 61 to 70 of about 363,783 (284)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Asia-Pacific consensus on the use of artificial intelligence in colorectal cancer screening and surveillance

iGIE
Background and Aims: Artificial intelligence (AI)-assisted colonoscopy has been widely investigated for colorectal adenoma and cancer detection and characterization.
Frederick H. Koh, PhD, James W. Li, MD, Sunny H. Wong, DPhil, Jonathan Lee, MD, Sneha John, FRACP, Vui Heng Chong, MD, Kai-chun Wu, MD, Rashid Lui, FRCP, Simon S.M. Ng, MD, Thomas Y.T. Lam, PhD, Louis H.S. Lau, MBChB, Govind K. Makharia, MD, Murdani Abdullah, MD, Hasan Maulahela, MD, Nozomu Kobayashi, MD, Masau Sekiguchi, MD, Jeong-Sik Byeon, MD, Hyun-soo Kim, MD, Yeong Yeh Lee, MD, Han-Mo Chiu, MD, I-Chen Wu, MD, Somchai Leelakusolvong, MD, Prateek Sharma, MD, David Lieberman, MD, Joseph J.Y. Sung, MD   +24 more
doaj   +1 more source

Dynamic Hyper-Graph Inference Framework for Computer-Assisted Diagnosis of Neurodegenerative Diseases

IEEE Transactions on Medical Imaging, 2019
Hyper-graph techniques have been widely investigated in computer vision and medical imaging applications, showing superior performance for modeling complex subject-wise relationships and sufficient flexibility to deal with missing data from multi-modal ...
Yingying Zhu, Xiaofeng Zhu, Minjeong Kim, Jin Yan, D. Kaufer, Guorong Wu   +5 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Role of Computer Aided Diagnosis (CAD) in Medical Imaging

Central Asian Journal of Medical Sciences, 2015
Objectives: We introduce the various methods of image analysis used for CAD. In addition, we provide a guide for the clinician through examples which use the CAD.
Seung Won Shin, Kwang Gi Kim
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Development of Machine Learning for Asthmatic and Healthy Voluntary Cough Sounds: A Proof of Concept Study

Applied Sciences, 2019
(1) Background: Cough is a major presentation in childhood asthma. Here, we aim to develop a machine-learning based cough sound classifier for asthmatic and healthy children.
Hwan Ing Hee, BT Balamurali, Arivazhagan Karunakaran, Dorien Herremans, Onn Hoe Teoh, Khai Pin Lee, Sung Shin Teng, Simon Lui, Jer Ming Chen   +8 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

A Comparative Study of the Diagnostic Performance of Evaluating Breast Masses for Breast Surgeons versus S-DetectTM(Samsung Medison Co., Ltd, Seoul, Korea)

Journal of Surgical Ultrasound, 2019
Purpose: Ultrasonography is widely used for examining breast mass. We used the Breast Imaging-Reporting and Data System (BI-RADS) to characterize breast lesions found on ultrasonography.
Haram Kim, Eiyoung Kwon, Youngsam Park, Eunhye Choi, Mijin Kim, Cheolseung Kim   +5 more
doaj   +1 more source