Results 61 to 70 of about 3,280,705 (273)

Multiscale Circuit Architecture Associated With Memory Dysfunction in Temporal Lobe Epilepsy

Advanced Science, EarlyView.
A multiscale precision‐mapping framework reveals that memory impairment in temporal lobe epilepsy arises from the convergence of focal medial temporal pathology, strategic white matter disconnection, and limbic‐centered metabolic network dysfunction.
Jiajie Mo, Qiwen Yuan, Pengfei Zhang, Lin Sang, Zhong Zheng, Baotian Zhao, Xiu Wang, Chao Zhang, Wenhan Hu, Xiaoqiu Shao, Jianguo Zhang, Ruijin Yang, Kai Zhang   +12 more
wiley   +1 more source

Improving the treatment of patients with dual diagnosis in emergency departments

, 2020
Dual diagnosis involves the co-occurrence of severe mental illness and substance misuse. Recent guidance has sought to improve the initial identification of dual diagnosis and the ongoing management of patients with confirmed dual diagnoses.
Willmann, T.
core   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Teaching the use of framing and decontextualization to address context-based bias in psychiatry [PDF]

, 2020
The framing effect in medical decision making is a type of cognitive bias that can lead a medical trainee at undergraduate and graduate level to reach a diagnosis or take action based on emotional states induced by the frame in which the information has ...
Sleilaty, Ghassan S., Nemr, E., Bou-Khalil, Rami, El-Khoury, Joseph R.   +3 more
core   +1 more source

Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy

Advanced Science, EarlyView.
A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan, Yuling Xu, Ting Yu, Yang Li, Xin Jiang, Haoyu Jin, Haitao Li, Youyu Zhang, Peng Yin, Jong Seung Kim   +9 more
wiley   +1 more source

Uncovering Capgras delusion using a large-scale medical records database

BJPsych Open, 2017
Background Capgras delusion is scientifically important but most commonly reported as single case studies. Studies analysing large clinical records databases focus on common disorders but none have investigated
Vaughan Bell, Caryl Marshall, Zara Kanji, Sam Wilkinson, Peter Halligan, Quinton Deeley   +5 more
doaj   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Psychogenic Non-epileptic Seizures and Pseudo-Refractory Epilepsy, a Management Challenge

Frontiers in Neurology, 2020
Psychogenic nonepileptic seizures (PNES) are neurobehavioral conditions positioned in a gray zone, not infrequently a no-man land, that lies in the intersection between Neurology and Psychiatry.
Francesca Anzellotti, Fedele Dono, Fedele Dono, Giacomo Evangelista, Martina Di Pietro, Claudia Carrarini, Claudia Carrarini, Mirella Russo, Mirella Russo, Camilla Ferrante, Stefano L. Sensi, Stefano L. Sensi, Stefano L. Sensi, Marco Onofrj, Marco Onofrj   +14 more
doaj   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Prevalence of dual diagnosis and clinical-epidemiological profile of patients followed at a specialized psychoactive substance outpatient clinic at FMABC

ABCS Health Sciences
INTRODUCTION: Substance Use Disorders (SUD) are a major public health challenge with high morbidity and mortality. Diagnostic complexity increases with the coexistence of additional mental disorders, known as Dual Diagnosis (DD).
Ana Laura Donaire Rapozero, Fábio Bernardes, Beatriz Okamura Monteiro, Henrique Soares Paiva   +3 more
doaj   +1 more source