Results 41 to 50 of about 1,517,013 (303)

Tailored for Real-World: A Whole Slide Image Classification System Validated on Uncurated Multi-Site Data Emulating the Prospective Pathology Workload. [PDF]

, 2020
Standard of care diagnostic procedure for suspected skin cancer is microscopic examination of hematoxylin & eosin stained tissue by a pathologist. Areas of high inter-pathologist discordance and rising biopsy rates necessitate higher efficiency and ...
Ayyagari, Devi, Bonham, Michael J., Chamarthi, Ramachandra Vikas, Cockerell, Clay J., Feeser, Theresa A., Ianni, Julianna D., Lee, Jason B., Motaparthi, Kiran, Olsen, Thomas G., Sankarapandian, Sivaramakrishnan, Soans, Rajath E., Stavish, Coleman C.   +11 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A vine copula mixed effect model for trivariate meta-analysis of diagnostic test accuracy studies accounting for disease prevalence [PDF]

, 2015
A bivariate copula mixed model has been recently proposed to synthesize diagnostic test accuracy studies and it has been shown that it is superior to the standard generalized linear mixed model in this context.
Aas K, Aristidis K Nikoloulopoulos, Brenner H, Chu H, Chu H, Demidenko E, Genest C, Genest C, Genest C, Hamza TH, Hoyer A, Hua L, Hult H, Joe H, Joe H, Joe H, Joe H, Joe H, Karageorgopoulos DE, Kurowicka D, Kuss O, Leeflang MMG, Leeflang MMG, Ma X, Mavridis D, McNeil AJ, Nash JC, Nelsen RB, Nikoloulopoulos AK, Nikoloulopoulos AK, Nikoloulopoulos AK, Nikoloulopoulos AK, Nikoloulopoulos AK, Nikoloulopoulos AK, Nikoloulopoulos AK, Panagiotelis A, Paul M, Serfling RJ, Shen C, Stroud AH, Vuong QH, Ye Y   +41 more
core   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Diagnostic accuracy of sonohysterography vs hysteroscopy in benign uterine endocavitary findings [PDF]

, 2015
OBJECTIVE: To compare diagnostic accuracy of sonohysterography vs hysteroscopy in patients with benign uterine endocavitary findings. PATIENTS AND METHODS: This retrospective study evaluated 202 patients submitted to sonohysterography after transvaginal ...
Bianchi, Paola, Caserta, Donatella, Catalano, Angelica, Cozza, Giuliana, DI PROPERZIO, Matilde, Frega, Antonio, Gentile, M, Manzara, F, Marziani, Rosalia, Milazzo, Gn, Schimberni, Mauro, Torcia, Francesco, Zinna, M   +12 more
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Time-efficient fault detection and diagnosis system for analog circuits [PDF]

, 2018
Time-efficient fault analysis and diagnosis of analog circuits are the most important prerequisites to achieve online health monitoring of electronic equipments, which are involving continuing challenges of ultra-large-scale integration, component ...
He, Yigang, Luo, Qiwu, Sun, Yichuang
core   +3 more sources

Systematic Reviews of Diagnostic Test Accuracy [PDF]

Annals of Internal Medicine, 2008
More and more systematic reviews of diagnostic test accuracy studies are being published, but they can be methodologically challenging. In this paper, the authors present some of the recent developments in the methodology for conducting systematic reviews of diagnostic test accuracy studies.
Leeflang, MMG, Deeks, JJ, Gatsonis, C, Bossuyt, PMM, Aertgeerts, B, Altman, D, Antes, G, Bachmann, L, Buchner, H, Bunting, P, Buntinx, F, Craig, J, D'Amico, R, de Vet, R, Doust, J, Egger, M, Eisinga, A, Fillipini, G, Flack-Ytter, Y, Glas, A, Glasziou, P, Grossenbacher, F, Harbord, R, Hilden, J, Hooft, L, Horvath, H, Hyde, C, Irwig, L, Kjeldstrøm, M, Macaskill, P, Mallett, S, Mitchell, R, Moore, THM, Moustgaard, R, Oosterhuis, W, Pai, M, Paliwal, P, Pewsner, D, Reitsma, H, Riis, J, Riphagen, I, Rutjes, A, Scholten, R, Smidt, N, Sterne, J, Takwoingi, Y, van der Windt, D, Vlassov, V, Watine, J, Whiting, P   +49 more
openaire   +5 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A PROSPECTIVE STUDY ON EVALUATION OF DIAGNOSTIC PERFORMANCE OF GENEXPERT MTB IN CSF FOR EARLY DIAGNOSIS OF TUBERCULAR MENINGITIS IN A TERTIARY CARE HOSPITAL ODISHA.

Student's Journal of Health Research Africa, 2023
Aim The study aims to establish the diagnostic accuracy of GeneXpert MTB/RIF in CSF for early diagnosis of tubercular meningitis and to compare the efficacy of CSF GeneXpert MTB/RIF with CSF culture for mycobacterium.
Aditya Narayan Sahu, Asit Kumar Mallick, Suman Kumar Jagaty, Saswat Subhankar, Debasis Behera, Sankarsan Das   +5 more
doaj