Results 101 to 110 of about 1,030,441 (312)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Clinical features and diagnostic performance for validation cohort.

, 2018
Clinical features and diagnostic performance for validation cohort.
Yoon Jin Lee (2940390), Young Hoon Kim (554681), Gabin Yun (5040320), Won Chang (840261), Hae Young Kim (3560063), Bohyoung Kim (2940384)   +5 more
core   +1 more source

Methylation analysis and diagnostics of Beckwith-Wiedemann syndrome in 1,000 subjects [PDF]

, 2014
BackgroundBeckwith-Wiedemann syndrome (BWS), a congenital overgrowth disorder with variable expressivity and a predisposition to tumorigenesis, results from disordered expression and/or function of imprinted genes at chromosome 11p15.5.
Kirby, Gail, MacDonald, Fiona, Dias, Renuka P, Hardy, Carol, Lim, Derek, Renuka P Dias, Eamonn R Maher, Abdulla Ibrahim, Louise Tee, Derek Lim, Jonathan Berg, Tee, Louise, Berg, Jonathan; id_orcid, Carol Hardy, Dias, Renuka P., Maher, Eamonn R., Peter Nightingale, Ibrahim, Abdulla, Berg, Jonathan, Nightingale, Peter, Maher, Eamonn R, Gail Kirby, Fiona MacDonald   +22 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Diagnostic value of demographical, clinical and radiological features.

, 2018
Diagnostic value of demographical, clinical and radiological features.
Marion Herbette (5533373), Alain Saraux (356420), Aleth Perdriger (415349), Béatrice Bouvard (132720), Laurie Joffres (5533361), Charlotte Lucas (5533364), Jérôme Guinard (317459), Emilie Ricard (5533367), Elisabeth Solau-Gervais (5533358), Carine Salliot (5533355), Jean Baptiste Cren (5533370)   +10 more
core   +1 more source

Pompe disease clinical and laboratory diagnostic features

Zdorovʹe Rebenka, 2017
Background. Analysis of Pompe disease (PD) clinical features in children in order to determine its main clinical and laboratory characteristics based on the results of laboratory and instrumental studies that allow to select such patients into the ...
N.O. Pichkur, N.V. Olkhovych, T.P. Ivanova, N.V. Samonenko   +3 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Deep learning versus classical neural approach to mammogram recognition [PDF]

Bulletin of the Polish Academy of Sciences: Technical Sciences, 2018
J. Kurek, B. Świderski, S. Osowski, M. Kruk, W. Barhoumi   +4 more
doaj   +1 more source

CHOROIDAL OSTEOMA: CLINICAL AND DIAGNOSTIC FEATURES

Паёми Сино, 2019
Objective: To present own experience of choroidal osteoma (CO) management. Methods: The study included 4 patients (4 eyes), who were monitored from 2018 to 2019. The age of the patients ranged from 17 to 45 years (average age – 29 years). According to
A.A. YAROVOY, V.A. YAROVAYA, D.S. ASTARKHANOVA, S.S. KLEYANKINA   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source