Results 121 to 130 of about 1,030,441 (312)

Polycystic ovary syndrome (PCOS) diagnostic features and use of medication.

open access: yes, 2018
Polycystic ovary syndrome (PCOS) diagnostic features and use of medication.
Krishna M. Gokhale (5028704)   +9 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Features of the immunohistochemical diagnostics of neuroendocrine tumors.

open access: yesMorphologia, 2015
Background. The possibility of neuroendocrine tumor (NET) development from almost any organ causes problems in determination of a true primary site after detection of such metastases in lymph nodes or liver. It impels to consider the expression of immunohistochemical organ-specific markers such as cytokeratin (СК) along with the morphological ...
openaire   +4 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Diagnostic imaging of psoriatic arthritis. Part I: etiopathogenesis, classifications and radiographic features

open access: yes, 2016
Psoriatic arthritis is one of the spondyloarthritis. It is a disease of clinical heterogenicity, which may affect peripheral joints, as well as axial spine, with presence of inflammatory lesions in soft tissue, in a form of dactylitis and enthesopathy.
Brygida Kwiatkowska   +7 more
core   +1 more source

ANALYSIS OF ECG SIGNALS BY DIVERSE AND COMPOSITE FEATURES

open access: yesElectrica, 2007
In this study, the automated diagnostic systems employing diverse and composite features for electrocardiogram (ECG) signals were analyzed and their accuracies were determined.
Elif Derya ÜBEYLİ
doaj   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

THE FEATHER’S DIAGNOSTIC FEATURES OF GALLIFORMES

open access: yesТеория и практика судебной экспертизы, 2014
Microstructure of the contour feathers (remex and covert) of 9 species has been compared:Bonasa bonasia, Tetrao urogallus, Lagopus lagopus, Lyrurus tetrix, Coturnix coturnix,Perdix perdix, Francolinus francolinus, Phasianus colchichus, Gallus gallus ...
O. Chernova, O. Silaeva, T. Perfilova
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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