Results 61 to 70 of about 451,576 (309)

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images [PDF]

open access: yes, 2018
Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA
Abdel-Rahman, Mohamed H.   +740 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Suffering as a Diagnostic Indicator

open access: yes, 2021
Pain is the subjective sensation closely related to disease and treatment. Very often its diagnosis is more an expression of the diagnostician’s experience than a description of the patient’s actual condition. In particular, orthopedic and neurological patients who develop Complex Regional Pain Syndrome are misdiagnosed because the intensity of their ...
Marek, Rózycki,, Robert, Tobias,
openaire   +3 more sources

Near-infrared spectroscopy of stellar populations in nearby spiral galaxies

open access: yes, 2012
We present high spatial resolution, medium spectral resolution near-infrared (NIR) H- and K-band long-slit spectroscopy for a sample of 29 nearby (z < 0.01) inactive spiral galaxies, to study the composition of their NIR stellar populations.
Ali   +75 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Impact of a combination of quantitative indices representing uptake intensity, shape, and asymmetry in DAT SPECT using machine learning: comparison of different volume of interest settings

open access: yesEJNMMI Research, 2019
Background We sought to assess the machine learning-based combined diagnostic accuracy of three types of quantitative indices obtained using dopamine transporter single-photon emission computed tomography (DAT SPECT)—specific binding ratio (SBR), putamen-
Yu Iwabuchi   +9 more
doaj   +1 more source

Deep learning as a novel method for endoscopic diagnosis of chronic atrophic gastritis: a prospective nested case–control study

open access: yesBMC Gastroenterology, 2022
Background and aims Chronic atrophic gastritis (CAG) is a precancerous disease that often leads to the development of gastric cancer (GC) and is positively correlated with GC morbidity.
Quchuan Zhao, Qing Jia, Tianyu Chi
doaj   +1 more source

Knowledge-based gene expression classification via matrix factorization [PDF]

open access: yes, 2008
Motivation: Modern machine learning methods based on matrix decomposition techniques, like independent component analysis (ICA) or non-negative matrix factorization (NMF), provide new and efficient analysis tools which are currently explored to analyze ...
A. M. Tomé   +47 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The association between different lipid indices and hyperuricemia in older adults: a cross-sectional study

open access: yesLipids in Health and Disease
Background Lipid-derived composite indices demonstrate robust epidemiological associations with diverse metabolic and cardiovascular disorders due to their integrative nature; however, their relationship with hyperuricemia (HUA) in older adults remains ...
Yingkai Shen   +4 more
doaj   +1 more source

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