Results 61 to 70 of about 98,319 (259)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Detection of Fractured Endodontic Instruments in Periapical Radiographs: A Comparative Study of YOLOv8 and Mask R-CNN

Diagnostics
Background/Objectives: Accurate localization of fractured endodontic instruments (FEIs) in periapical radiographs (PAs) remains a significant challenge.
İrem Çetinkaya, Ekin Deniz Çatmabacak, Emir Öztürk   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Fault diagnosis method for substations based on fault enumeration tree to generate fuzzy Petri net

Gong-kuang zidonghua
To address the issues of complexity and difficulty of automatic modeling in Petri net fault diagnosis models that incorporate temporal information, a fault diagnosis method for substations based on generating fuzzy Petri nets from fault enumeration trees
WU Yulun, XIAO Tannan, CHEN Ying
doaj   +1 more source

FUZZY DIAGNOSTİCS OF SOİLS ACCORDİNG TO THE WORLD REFERENCE BASE FOR SOİL RESOURCES

Сучасні інформаційні системи, 2020
Soil classification remains one of the most controversial topics in the world soil science because of differences in the principles underlying it. As of today, many countries have developed and use their own national classifications.
Samira Afrasiyab Hasanova, Adalat Bakhtiyar Pashayev, Elhan Nariman Sabziev   +2 more
doaj   +1 more source

Application of logic 4-valued in the process of reasoning in diagnostic systems [PDF]

Biuletyn Wojskowej Akademii Technicznej, 2016
The article presents application of logic 4-valuable in the process of reasoning in diagnostic systems. For this purpose, the structure of an intelligent diagnostic system (DIAG 2) is presented and defined. Its essential modules: measurement, calculation,
Stanisław Duer, Konrad Zajkowski, Radosław Duer   +2 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A likelihood approach to diagnostic tests in clinical medicine

Revstat Statistical Journal, 2005
This paper presents a pure likelihood approach to statistical inference and its relation to diagnostic tests in clinical medicine. The standard antagonistic frequentist approaches of Fisher and Neyman–Pearson–Wald, and the Bayesian perspective are ...
Basílio de Bragança Pereira , Carlos Alberto de Bragança Pereira   +1 more
doaj   +1 more source