Results 71 to 80 of about 283,509 (287)

A likelihood approach to diagnostic tests in clinical medicine

Revstat Statistical Journal, 2005
This paper presents a pure likelihood approach to statistical inference and its relation to diagnostic tests in clinical medicine. The standard antagonistic frequentist approaches of Fisher and Neyman–Pearson–Wald, and the Bayesian perspective are ...
Basílio de Bragança Pereira , Carlos Alberto de Bragança Pereira   +1 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Explanation-based learning for diagnosis [PDF]

, 1992
Diagnostic expert systems constructed using traditional knowledge-engineering techniques identify malfunctioning components using rules that associate symptoms with diagnoses. Model-based diagnosis (MBD) systems use models of devices to find faults given
Fattah, Yousri El, O'Rorke, Paul
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

An interpretable machine learning method for fault diagnosis of oil-immersed transformers based on edge inference

International Journal of Electrical Power & Energy Systems
Intelligent diagnostic models using dissolved gas analysis are crucial for oil-immersed transformer fault diagnosis. However, the inherent “black box” nature of these models limits interpretability, and traditional methods that upload local data to ...
Dong Hu, Yong Yang, Hao Dai, Chao Tang, Jufang Xie   +4 more
doaj   +1 more source

Methodology of knowledge acquisition for machinery diagnostics

Computer Assisted Methods in Engineering and Science, 2023
The paper deals with a comprehensive methodology concerning knowledge acquisition on machinery for the purpose of expert systems suitable for aiding of diagnostic inference.
Wojciech Moczulski
doaj  

An Empirical Comparison of Three Inference Methods

, 2015
In this paper, an empirical evaluation of three inference methods for uncertain reasoning is presented in the context of Pathfinder, a large expert system for the diagnosis of lymph-node pathology.
Heckerman, David
core  

Score, Pseudo-Score and Residual Diagnostics for Spatial Point Process Models

, 2011
We develop new tools for formal inference and informal model validation in the analysis of spatial point pattern data. The score test is generalized to a "pseudo-score" test derived from Besag's pseudo-likelihood, and to a class of diagnostics based on ...
Baddeley, Adrian, Møller, Jesper, Rubak, Ege   +2 more
core   +1 more source