Results 81 to 90 of about 283,509 (287)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

An explainable deep learning framework for biosensing data interpretation in biomedical engineering and real-time health diagnostics

Frontiers in Bioengineering and Biotechnology
IntroductionThis work proposes an explainable deep learning framework to transform complex biosignal dynamics into interpretable health assessments.
Zheng Yang, Zheng Yang, Weihong Huang, Weihong Huang, Heng Zhang   +4 more
doaj   +1 more source

Logical–Linguistic Model of Diagnostics of Electric Drives with Sensors Support

Sensors, 2020
The presented paper scientifically discusses the progressive diagnostics of electrical drives in robots with sensor support. The AI (artificial intelligence) model proposed by the authors contains the technical conditions of fuzzy inference rule ...
Yury Nikitin, Pavol Božek, Jozef Peterka   +2 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Variational Bayesian Inference for a Q-Matrix-Free Hidden Markov Log-Linear Additive Cognitive Diagnostic Model

Algorithms
Cognitive diagnostic models (CDMs) are commonly used in educational assessment to uncover the specific cognitive skills that contribute to student performance, allowing for precise identification of individual strengths and weaknesses and the design of ...
Hao Duan, James Tang, Matthew J. Madison, Michael Cotterell, Minjeong Jeon   +4 more
doaj   +1 more source

FastVentricle: Cardiac Segmentation with ENet

, 2017
Cardiac Magnetic Resonance (CMR) imaging is commonly used to assess cardiac structure and function. One disadvantage of CMR is that post-processing of exams is tedious. Without automation, precise assessment of cardiac function via CMR typically requires
A Suinesiaputra, C Petitjean, C Pluempitiwiriyawej, J Bergstra, J Choa, JM Bland, M Kass, O Ronneberger, P Peng, W Zhu   +9 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Critical thinking in math: 10th-grade analysis using cognitive diagnostic modeling

REID (Research and Evaluation in Education)
Critical thinking is widely recognized as an essential competency in mathematics education, yet assessments often fail to capture its multidimensional nature.
Muhammad Ali Gunawan, Fitri Amalia, Ari Setiawan, Hawa Husna Ab Ghani   +3 more
doaj   +1 more source

Diagnosing faults in autonomous robot plan execution [PDF]

A major requirement for an autonomous robot is the capability to diagnose faults during plan execution in an uncertain environment. Many diagnostic researches concentrate only on hardware failures within an autonomous robot.
Atkinson, David J., Doshi, Rajkumar S., Lam, Raymond K., Lawson, Denise M.   +3 more
core   +1 more source

Bounding bias due to selection

, 2019
When epidemiologic studies are conducted in a subset of the population, selection bias can threaten the validity of causal inference. This bias can occur whether or not that selected population is the target population, and can occur even in the absence ...
Smith, Louisa H., VanderWeele, Tyler J.
core   +1 more source