Results 101 to 110 of about 2,994,342 (328)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
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FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
The role of strategy and redundancy in diagnostic reasoning
BMC Medical Education, 2003 Background Diagnostic reasoning is a key competence of physicians. We explored the effects of knowledge, practice and additional clinical information on strategy, redundancy and accuracy of diagnosing a peripheral neurological defect in the hand based on
Feller Sabine +3 more
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FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
BMC Medical EducationBackground Clinical reasoning is a professional capability required for clinical practice. In preclinical training, clinical reasoning is often taught implicitly, and feedback is focused on discrete outcomes of decision-making.
Lucinda E. Ainge +3 more
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Serious Games in Medical Education: What it Adds? How to Go about It?
Journal of Pharmacy and Bioallied SciencesMedical educators have adopted a number of teaching–learning methodologies to make their sessions interactive considering the need for active engagement of students to strengthen the process of learning.
Shrivastava Prateek Saurabh +1 more
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Deconstructing the diagnostic reasoning of human versus artificial intelligence
Canadian Medical Association Journal, 2019 KEY POINTS Artificial intelligence (AI) is often presented as the future of medical practice. The concept of AI was developed in the 1950s and has been defined as “the use of a computer to model intelligent behaviour with minimal human intervention.” [1][
T. Pelaccia +2 more
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FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
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Investigating The Problem of Misdiagnosis in Model–Based Fault Diagnosis
International Journal of Applied Mathematics and Computer ScienceThis paper deals with one partly unconscious property of the model-based diagnosis. It discusses occasional contradictions between diagnoses that are logically correct but, in fact, are not consistent with the physical state of the system being diagnosed.
Kóscielny Jan Maciej, Bartyś Michał
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