Results 71 to 80 of about 2,994,342 (328)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Examining fallacies in diagnostic reasoning [PDF]

Journal of Evaluation in Clinical Practice, 2013
The paper by Gurova takes issue with the claim of Meehl that ‘understanding makes it normal’ is a fallacy in diagnostic reasoning [1,2]. Her paper prompts the more general question of appropriate methods for testing whether a specific way of reasoning in making a clinical diagnosis is fallacious.
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Structured clinical reasoning prompt enhances LLM’s diagnostic capabilities in diagnosis please quiz cases

Japanese Journal of Radiology
Large Language Models (LLMs) show promise in medical diagnosis, but their performance varies with prompting. Recent studies suggest that modifying prompts may enhance diagnostic capabilities.
Yuki Sonoda, Ryo Kurokawa, Akifumi Hagiwara, Yusuke Asari, Takahiro Fukushima, Jun Kanzawa, W. Gonoi, Osamu Abe   +7 more
semanticscholar   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Intermittent Electrical Contact Resistance as a Contributory Factor in the Loss of Automobile Speed Control Functional Integrity

IEEE Access, 2014
For three decades, sudden acceleration (SA) incidents have been reported, where automobiles accelerate without warning. These incidents are often diagnosed as no fault found.
Antony F. Anderson
doaj   +1 more source

Teaching Diagnostic Reasoning to Faculty Using an Assessment for Learning Tool: Training the Trainer

MedEdPORTAL, 2020
Introduction There is a need for a standardized approach to understand and assess clinical reasoning in medical learners. The Assessment of Reasoning Tool was developed based on prevalent theories and frameworks using a multidisciplinary expert panel. As
Adam Cohen, M. Sur, Martin Weisse, K. Moffett, Jeffrey D. Lancaster, Renee B Saggio, Geeta R Singhal, S. Thammasitboon   +7 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Sum It Up for Me: A Novel Workshop in the Synthesis of Comprehensive Summary Statements for Pediatric Residents

MedEdPORTAL
Introduction The ACGME requires progressive monitoring of pediatric trainees’ clinical reasoning. Creation of summary statements is a core clinical reasoning skill because it requires learners to prioritize patient information and express their problem ...
Maritza T. Harper, Muyao Lin, Eliana Bonifacino   +2 more
doaj   +1 more source

Validation of a manual of care plans for people hospitalized with COVID‐19

Nursing Open, 2021
Aim Validate a manual of care plans for people hospitalized for coronavirus disease, COVID‐19. Design Validation study with a mixed‐method design. Methods Design and validation of a care plans manual for people hospitalized by COVID‐19.
Alexandra González Aguña, Marta Fernández Batalla, Javier Díaz‐Tendero Rodríguez, Juan Antonio Sarrión Bravo, Blanca Gonzalo de Diego, José María Santamaría García   +5 more
doaj   +1 more source