Results 121 to 130 of about 1,430,816 (305)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

National Diagnostic Reference Level (DRL) for nuclear medicine computed tomography-positron emission tomography hybrid imaging studies for kuwait population: second phase dose audit-2019. [PDF]

BJR Open, 2021
Masoomi M, Al-Shammeri I, Al-Kandari L, Elrahman H, Al-Shammeri J.   +4 more
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Advanced Computational Methods for Radiation Dose Optimization in CT

Diagnostics
Background: In planning radiotherapy treatments, computed tomography (CT) has become a crucial tool. CT scans involve exposure to ionizing radiation, which can increase the risk of cancer and other adverse health effects in patients.
Shreekripa Rao, Krishna Sharan, Srinidhi Gururajarao Chandraguthi, Rechal Nisha Dsouza, Leena R. David, Sneha Ravichandran, Mubarak Taiwo Mustapha, Dilip Shettigar, Berna Uzun, Rajagopal Kadavigere, Suresh Sukumar, Dilber Uzun Ozsahin   +11 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Diagnostic Reference Levels for Pediatric CT Examinations Based on Patient Size: A Meta-analysis [PDF]

Journal of Pediatrics Review
Background: Patient dose surveys are periodically performed to evaluate whether the patient’s doses are acceptable compared to the recommended and reported diagnostic reference levels (DRLs).
Seyed Salman Zakariaee, Negar Naderi, Hadi Kazemi-Arpanahi   +2 more
doaj  

Determination of Diagnostic Reference Level (DRL) in Common Computed Tomography Examinations with the Modified Quality Control-Based Dose Survey Method in Four University Centers: A Comparison of Methods. [PDF]

J Biomed Phys Eng, 2021
Tabesh J, Mahdavi M, Haddadi G, Ravanfar Haghighi R, Jalli R.   +4 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

An Approach to Establishing Diagnostic Reference Levels in Interventional Pediatric Cardiology from Different Regions of Brazil

Children
Diagnostic reference levels (DRLs) are a pivotal strategy to be implemented since pediatric interventional cardiology procedures are increasing. This work aimed to propose an initial set of Brazilian DRLs for pediatric interventional diagnostic and ...
Viviane K. Asfora, Marcelo B. Freitas, Regina B. Medeiros, Hugo R. Schelin, Akemi Yagui, Marcus V. L. Oliveira, Luiz M. S. A. Leite, Guillermo A. Lopez, Maryanna R. S. Roberto, Fabio L. Gagetti, Pablo H. O. Souza, Bruna Vargas, Valeriy V. Denyak, Helen J. Khoury   +13 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source