Results 121 to 130 of about 597,510 (287)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-γ for the evaluation of pleural tuberculosis: a prospective cohort study

, 2014
Background: The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer improved detection.
Jonny Peter, Greg Symons, Meldau, Richard, Symons, Greg, Calligaro, Greg, van Zyl-Smit, Richard, Gina Ntombenhle, Peter, Jonny, Hoosain Khalfey, Keertan Dheda, Grant Theron, Greg Calligaro, Brian Allwood, Anke Binder, Allwood, Brian, Govender, Ureshnie, Ntombenhle, Gina, Ureshnie Govender, Dheda, Keertan, Theron, Grant, Khalfey, Hoosain, Richard Meldau, Richard van Zyl-Smit, Binder, Anke   +23 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishing Local Diagnostic Reference Levels for CT Angiography Examinations

Journal of Health Science and Medical Research (JHSMR)
Objective: Computed tomography angiography (CTA) examinations are performed to diagnose blood vessel anomalies. However, this examination results in a significant radiation dose being received by the patient.
Abhimanyu Pradhan, Rajagopal Kadavigere, Suresh Sukumar   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Proposed Typical Diagnostic reference levels in paediatric radiography exams

The aim of this project is to study the doses delivered to children undergoing radiographic examinations in the radiology department of the mother and child hospital of the Mohammed VI University Hospital Centre in Marrakech (MCH- Med VI UHC-M), and to ...
Hassan Khajmi, Abdessamad Tounsi. Lhoucine Oufni, Abdelfattah Mounir   +2 more
core   +1 more source

Nigerian Radiographers Obligation to Diagnostic Reference levels (DRLs) in Medical Imaging

, 2020
Background: Diagnostic reference levels (DRLs) help to identify unusually high dose levels in medical procedures involving radiation. This will subsequently, stimulate quality control.
Adejoh, Tom
core  

Optimizing Patient Protection During Diagnostic Procedures -Developing Diagnostic Reference Levels at the Dr George Mukhari Hospital [PDF]

, 2010
Thesis (MSc.(Med)(Physics))--University of Limpopo, 2010.Key words: Diagnostic reference levels (DRL), entrance surface dose (ESD), thermoluminescence dosimetry (TLD) Introduction: Diagnostic reference levels (DRL‟s) are defined as a dose level set for ...
Dumela, Khombo Eunice
core  

Establishing diagnostic criteria: the role of clinical pragmatics

, 2012
The study of pragmatic disorders is of interest to speech-language pathologists who have a professional responsibility to assess and treat communication impairments.
Cummings, L
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source