Results 121 to 130 of about 12,449,625 (324)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Proposal of National Diagnostic Reference Levels for Selected General Radiography Procedures in Ghana [PDF]

Journal of Radiation Protection and Research
Background Diagnostic reference levels (DRLs) are integral to optimizing the patient dose in diagnostic radiology, and yet data for low- and middle-income countries are limited.
Daniel Abbeyquaye, Stephen Inkoom, Shirazu Issahaku, Theresa Bebaaku Dery, David Ebo Anderson, Van Wellington Elloh   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Estimation of Typical Values (DRL) in Angioplasties Performed at a Radiology Service of a Hospital in Southern Brazil

Brazilian Journal of Radiation Sciences
Interventional radiology involves diagnostic and therapeutic interventions using X-ray-emitting equipment. Due to the high radiation doses administered to patients during these procedures, there is a significant risk of severe tissue reactions resulting ...
Fernando Rockembach Mazuim, Isadora Tomanqueves Costa, Florencia Agustina Gutierrez Perez, Cristiny Tretto Lemes Pereira Dutra, Marcos Araquem Scopel, Tiago Trindade Hahn, Catia Simone Griebler Gomes, Daiane Cristini Barbosa Souza   +7 more
doaj   +1 more source

Patient dose audit of the most frequent radiographic examinations and the proposed local diagnostic reference levels in southwestern Nigeria: Imperative for dose optimisation

Journal of Radiation Research and Applied Sciences, 2016
Diagnostic reference levels (DRLs) is a veritable tool for dose optimisation and patient protection in diagnostic radiology. However, it is essential to have information on the local situation especially in a large hospital with several units or a ...
N.N. Jibiri, C.J. Olowookere
doaj   +1 more source

Comparison of Local Diagnostic Reference Levels with National Diagnostic Reference Levels for Diagnostic Examinations in Adult Nuclear Medicine at a Specific Designated Facility [PDF]

Ve své práci v teoretické části popisuji úvod do radiační ochrany, převážně pak její obecný vývoj a principy s konkrétním zaměřením na princip aplikace dávkových limitů.
Vojtěch Novotný
core  

Cost-effectiveness of diagnostic laparoscopy for assessing resectability in pancreatic and periampullary cancer. [PDF]

, 2015
Surgical resection is the only curative treatment for pancreatic and periampullary cancer, but many patients undergo unnecessary laparotomy because tumours can be understaged by computerised tomography (CT).
Morris, S, Gurusamy, KS, Davidson, BR, Kurinchi S Gurusamy, Stephen Morris, Sheringham, J, Brian R Davidson, Jessica Sheringham   +7 more
core   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source