Results 51 to 60 of about 1,116,177 (240)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Multiplex lateral flow assay development for snake venom detection in biological matrices
Scientific ReportsBothrops and Lachesis are two of Brazil’s medically most relevant snake genera, causing tens of thousands of bites annually. Fortunately, Brazil has good accessibility to high-quality antivenoms at the genus and inter-genus level, enabling the treatment ...
Cecilie Knudsen +8 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Application of Local Influence Diagnostics to the Linear Logistic Regression Models [PDF]
This paper focuses the development of the diagnostics for the perturbations of case-weights and explanatory variables (one or more) in a linear logistic regression model.
M. ATAHARUL ISLAM, MONZUR HOSSAIN
core
The CRC dataset contains 1132 colorectal biopsy and polypectomy WSIs (svs. files), retrieved from the data archive of IMP Diagnostics laboratory, Portugal, digitised at 40X by 2 Leica GT450 WSI scanners.
IMP Diagnostics and INESC-P
core +1 more source
Quantitative laser-induced fluorescence: some recent developments in combustion diagnostics [PDF]
, 1990 Kohse-Höinghaus K. Quantitative laser-induced fluorescence: some recent developments in combustion diagnostics. Applied Physics, B. 1990;50(6):455-461.This report summarizes several recent applications of quantitative laser-induced fluorescence ...
Kohse-Höinghaus, K. +1 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
NOAA-GFDL/MDTF-diagnostics: Version 3.0.1
, 2023 What's Changed Add a tool to convert file names to the default Local_file format by @wrongkindofdoctor in https://github.com/NOAA-GFDL/MDTF-diagnostics/pull/438 Add option to bypass the preprocessor by @wrongkindofdoctor in https://github.com/NOAA-GFDL ...
Thomas Jackson +11 more
core +1 more source