Results 61 to 70 of about 1,116,177 (240)

Lab on a bead with oscillatory centrifugal microfluidics for fast and complete mixing enables fast and accurate biomedical assays

Scientific Reports
Rapid mixing and precise timing are key for accurate biomedical assay measurement, particularly when the result is determined as the rate of a reaction: for example rapid immunoassay in which the amount of captured target is kinetically determined ...
David E. Williams, Wei Li, Mithileshwari Chandrasekhar, Carsten Ma On Wong Corazza, Gerrit Sjoerd Deijs, Lionel Djoko, Bhavesh Govind, Ellen Jose, Yong Je Kwon, Tiffany Lowe, Anil Panchal, Gabrielle Reshef, Matheus J. T. Vargas, M. Cather Simpson   +13 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Diagnostics

, 2015
These codes compute various diagnostics on the fitted ...
Pejman Rohani (208881), Magpantay, Felicia, Felicia Magpantay (3282105), Matthieu Domenech (3282102), Aaron A. King (208879), Rohani, Pejman, King, Aaron A., Domenech, Matthieu   +7 more
core   +1 more source

Development and analytical performance of a new research use only (RUO) GP73 automated immunoassay

Biochemistry and Biophysics Reports
Golgi protein 73 (GP73) is a serum marker with potential applications in the assessment of chronic liver disease progression. We developed a research use only (RUO) GP73 immunoassay to detect serum GP73 concentration.
Shaohua Ning, Enfu Liu, Fanju Meng, Fei Chen, James Hartnett, Zhihong Lin, Bailin Tu, David J. Hawksworth, Bryan C. Tieman, De Yu Mao, Ryan Piktel, Amit Kumar, You Pan, Philip M. Hemken   +13 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Extracellular vesicles from plasma have higher tumour RNA fraction than platelets

Journal of Extracellular Vesicles, 2020
In addition to Circulating Tumour Cells (CTCs), cell-free DNA (cfDNA) and Extracellular Vesicles (EVs), the notion of “Tumour-Educated Platelets” (TEP) has recently emerged as a potential source of tumour-derived biomarkers accessible through blood ...
Kay Brinkman, Lisa Meyer, Anne Bickel, Daniel Enderle, Carola Berking, Johan Skog, Mikkel Noerholm   +6 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Evaluation of tuberculosis diagnostics: establishing an evidence base around the public health impact. [PDF]

, 2011
The limitations of existing tuberculosis diagnostic tools are significantly hampering tuberculosis control efforts, most noticeably in areas with high prevalence of human immunodeficiency virus (HIV) infection and antituberculosis drug resistance ...
Newell, Marie-Louise, Graham S. Cooke, Marie-Louise Newell, Cooke, Graham S, Peter Godfrey-Faussett, Richard J. Lessells, Lessells, Richard J, Godfrey-Faussett, Peter   +7 more
core   +1 more source

NOAA-GFDL/MDTF-diagnostics: Version 3.2

, 2023
What's Changed add esm intake catalog builder tool by @wrongkindofdoctor in https://github.com/NOAA-GFDL/MDTF-diagnostics/pull/453 Update cmor tables by @wrongkindofdoctor in https://github.com/NOAA-GFDL/MDTF-diagnostics/pull/454 add Feature/stc annular
Thomas Jackson, ahbutlerwx, Tom Jackson, Geraldine Nelly Emlaw, climate_kid, John Krasting, Dani Coleman, jcstarr, Aparna Radhakrishnan, yihungkuo, Wenhao@GFDL, Zac Lawrence, Cecilia Bitz, Jess   +13 more
core   +1 more source