Results 101 to 110 of about 808,226 (293)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Robust ODL beamformer for enhanced DOA estimation and performance comparison with MVDR

Discover Electronics
Accurate direction of arrival (DOA) estimation is critical for effective source localization in radar, sonar, and wireless communication systems. However, conventional Minimum Variance Distortionless Response (MVDR) beamformers suffer significant ...
Md. Kamrul Hasan, Sonia Siddiki, Mohammad Ruhul Amin Bhuiyan, Jubaer Ahamed Bhuiyan, Hayati Mamur, K. M. Fysal Kabir   +5 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Adaptive Diagonal Loading for Norm Constrained Beamforming

Reliable adaptive beamforming is critical for large microphone arrays operating in highly dynamic acoustic environments. In scenarios characterized by fast-moving talkers and interferers, the available sample support for estimating the spatial correlation matrix is often snapshot-deficient.
Mittal, Manan, Corey, Ryan M., Buck, John R., Singer, Andrew C.   +3 more
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Study on the Crack Propagation Behavior and Patterns of High-Speed Railway Bridges Under High-Speed Train Loading

Advances in Civil Engineering
This study focuses on simply supported railway box girder bridges with pre-existing cracks under high-speed train loading. A vehicle–bridge coupled vibration model is established, and three-dimensional dynamic stress intensity factors at the crack tip ...
Wei-biao Zhang, Sheng-hui Liu, Yan Wang, Jing Lin, Wen-jie Shi, Shi-ke Hu, Lie-ni Wang, Zi-hao Li   +7 more
doaj   +1 more source

Vers un autre chemin d'accès au logement

, 2019
Marie-Hélène Bacqué est professeure en études urbaines à l’université Paris-Nanterre. Elle travaille sur la démocratie urbaine en France et aux États-Unis et s’intéresse depuis de nombreuses années à l’habitat participatif.
Revue d'urbanisme Diagonal
core  

An Invariant Geometric Feature for Inter-Subject Lumbar Curve Alignment to Detect Spondylolisthesis

IEEE Access
Spondylolisthesis classification commonly relies on the shift distance (SD) feature. This feature measures the displacement between vertebrae but is sensitive to variations in size and rotational alignment of the vertebrae.
Podchara Klinwichit, Watcharaphong Yookwan, Athita Onuean, Paramate Horkaew, Sornsupha Limchareon, Jun-Su Jang, Suwanna Rasmequan, Krisana Chinnasarn   +7 more
doaj   +1 more source